TLDR Combining vertical and horizontal sectioning improves scalp biopsy analysis for alopecia.
The study analyzed scalp biopsies from 40 patients with alopecia to understand the histological changes in various types of alopecia and the benefits of combining vertical and horizontal sectioning. Scarring and non-scarring alopecia were almost equally represented, with lichen planopilaris being the most common variant of scarring alopecia. The study highlighted the need for immunofluorescence studies in cases of scarring alopecia due to overlapping microscopic features. Alopecia areata was identified as the most common cause of hair loss, diagnosed by peribulbar inflammation and nanogen hair follicles. The research suggested that combining vertical and transverse sectioning allows for a more thorough examination of scalp biopsies.
17 citations
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September 2012 in “Dermatologic Clinics” The conclusion is that accurate diagnosis of different types of hair loss requires careful examination of tissue samples and understanding of clinical symptoms.
11 citations
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October 2011 in “Dermato-endocrinology” Many alopecia patients have undetected thyroid abnormalities that can be found through physical exams.
3 citations
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April 2010 in “The American Journal of Dermatopathology” Most people with scarring and nonscarring hair loss show similar D2-40 levels, but some with scarring hair loss have higher levels.
9 citations
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November 2009 in “Journal of the European Academy of Dermatology and Venereology” Cutting scalp biopsies in consecutive slices improves diagnosis of hair loss conditions.
December 2013 in “Research Portal (King's College London)” Hair loss in Lichen Planopilaris is caused by immune system issues damaging hair follicles and stem cells.
11 citations
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April 2016 in “The American Journal of Dermatopathology” Special and immunohistochemical stains are not routinely needed for diagnosing hair disorders.
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