Identification and Detection of Finasteride Polymorphs in Finasteride Tablets by FT-Raman Spectroscopy

    January 2020 in “ Asian Journal of Chemistry ”
    M. S. Ramachandra Rao, R. Ramakrishna Reddy, K.B. Chandra Sekhar, Y.C. Janardhan Reddy
    TLDR Raman spectroscopy can identify finasteride polymorphs in tablets.
    The study developed a simple FT-Raman spectroscopic method to identify finasteride polymorphs in tablets, specifically detecting polymorph form I used in tablet preparation, which constituted about 2.3% of the tablet's weight. The method successfully identified the polymorphic form and detected up to 15% of another polymorph in the solid dosage. Various techniques, including powdered X-ray diffraction, infrared spectroscopy, and Raman spectroscopy, were used to characterize the dosage form, with Raman spectroscopy being the only method capable of identifying the polymorph in the dosage form.
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