Drug Polymorphism Identification Using Fourier Transform-Raman Spectroscopy: A Comparative Study of Lamivudine and Finasteride Drugs

January 2021 in “ Asian Journal of Pharmaceutical and Clinical Research ”

Chandra Sekhara Rao M, Chenna Krishna Reddy R, Chandra Sekhar Kb, Rami Reddy Yv

finasteride Fourier Transform-Raman spectroscopy polymorphism X-ray powder diffraction Propecia FT-Raman spectroscopy

TLDR FT-Raman spectroscopy is effective for identifying drug polymorphs, ensuring quality and stability.

The study compared the effectiveness of Fourier Transform-Raman (FT-Raman) spectroscopy in detecting polymorphism in Lamivudine and Finasteride drugs. The authors highlighted that FT-Raman spectroscopy provided sharp, well-resolved bands and did not suffer from sampling issues common in other techniques like X-ray powder diffraction. The results demonstrated that FT-Raman spectroscopy is advantageous for identifying polymorphic forms, ensuring drug quality and stability.

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