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This study found that hair follicle stem cells can proliferate and differentiate into keratinocytes on chitosan skin-engineered templates, suggesting potential applications in regenerative medicine.

This review discusses recent advances in using stem cells for skin repair and regeneration after severe burn injuries, but it reports no new clinical results.

In this study, researchers achieved complete reepithelialization and hair growth on a burn-injured scalp using a tissue-engineered dermal template with early micrograft hair follicle implantation.

In this study, researchers used a CRISPR-based method to correct mutations in the COL7A1 gene in stem cells from RDEB patients, restoring normal collagen expression in engineered skin grafts in mice.

This study demonstrated in rodent models that artificial dermal template treatment can induce full-thickness skin regrowth including skin epidermis and adnexa without the need for autologous skin grafts.

This review discusses the use of dermal regeneration templates for treating burn injuries and other wounds, highlighting their effectiveness in reducing scars and aiding in regenerative processes, but reports no new clinical results.

This review discusses strategies for regenerating cutaneous nerve function in burn patients and highlights the potential role of autologous skin-derived adult stem cells in improving sensory recovery, but reports no new experimental findings.

This study found that engineered skin substitutes made with skin-derived precursors and epidermal stem cells can regenerate hair follicles after grafting into nude mice.

This article discusses the applications and contraindications of skin grafts in wound treatment and reports no new research findings.

New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.

This review discusses the modern approach of skin tissue engineering for chronic wound treatment, focusing on bioengineered artificial skin substitutes and assessing innovations in biomaterials and cell use; it reports no new clinical results.

This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.

This study found that using 3D Gel-C6S-HA scaffolds seeded with VEGF165-modified rat hair follicle stem cells enhanced angiogenesis and vascularization in tissue-engineered skin, improving wound healing.

This study found that the FGF-2 mimetic SUN11602 and VEGF mimetic ONO-1301 had unique effects on skin fibroblasts and keratinocytes, indicating potential for improving wound healing.

This review discusses the challenges of skin graft acceptance and examines current strategies and alternatives for full-thickness skin replacement and repair, noting that immunological rejection remains a significant hurdle.

This chapter reviews the use of electrospun matrices in creating tissue-engineered skin substitutes and reports no new clinical results; it emphasizes the need for a cell-friendly microenvironment.

New therapies for burn wounds show promise in reducing pain, infection risk, and improving healing and physical outcomes.

This review synthesizes current advances in transcriptomics and RNA regulatory networks, alongside stem cell-derived skin organoid research, to propose a conceptual framework for understanding and potentially guiding regenerative skin repair, without claiming clinical readiness.

This chapter reviews traditional and tissue-engineered treatments for skin defects and discusses advances in bioengineered skin constructs, but it presents no new experimental results.

This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.

This study suggests that human hair keratin-based gradient hydrogels incorporating silver ions may serve as promising dermal templates for wound healing, demonstrating favorable mechanical properties, cell interaction, and antibacterial activity.

This review explores the potential of multifunctional bioscaffolds in skin tissue engineering, highlighting their successful biological performance in vitro and in vivo animal models, while also identifying the demand for technological advancements to improve wound healing applications in clinical settings.

This study found that rat hair follicle stem cells can be effectively transfected with VEGF 165 using lentivirus vectors, suggesting their potential use in developing tissue-engineered skin with improved vascularization.

In this study, researchers successfully constructed a high-precision three-dimensional model of human skin dermis, revealing a detailed analysis of dermal porosity and pore diameter distribution, which can aid the development of biomimetic tissue-engineered skin.

This chapter reviews therapies for skin and corneal regeneration and hair loss, discussing various treatments but presenting no new research findings.

In this study, oil body-bound oleosin-rhFGF-10 was more efficiently absorbed through the skin and enhanced wound healing and hair growth in mice, compared to prokaryotically-expressed rhFGF-10.

This review discusses the advancements in biologic skin substitutes for wound treatment and their potential in enhancing cutaneous regeneration but reports no new clinical results.

This review describes how the skin can form its own immune response through dermal tertiary lymphoid organs, which function independently of traditional lymph nodes, potentially offering new insights into skin health care and treatments.

This review highlights the potential of bioengineered dermal scaffolds in tissue engineering to enhance wound healing by mimicking the dermal structure and supporting cellular processes, while also discussing recent advancements and challenges in scaffold technology.