Template for Skin Regeneration

The document from January 1, 2011, outlines the effectiveness and clinical applications of a dermal regeneration template (DRT) in skin regeneration, particularly for burn victims and reconstructive surgery. The DRT, which includes a silicone layer and a collagen-glycosaminoglycan scaffold, has been shown to reduce scarring and promote dermal regeneration. It has been used in various clinical settings, with a multicenter study involving 841 burn sites in 216 patients showing a 76.2% mean take rate of DRT and an 87.5% mean take rate of thin epidermal autograft. The document highlights the importance of proper application and monitoring to reduce infection and maximize effectiveness. Long-term results indicate that DRT-treated skin can achieve elasticity comparable to normal skin. Future improvements may allow for single-stage skin regeneration by seeding the template with keratinocytes and could include simultaneous hair restoration for calvarial defects. The DRT has been approved by the FDA and is considered a valuable tool for plastic surgeons, with ongoing research to enhance its regenerative capabilities and cost-effectiveness.