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The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

Apoptosis is essential for human skin development and forming a functional epidermis.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Noggin is necessary to start the hair growth phase in skin after birth.

The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Estrogen therapy can reduce skin aging but has cancer risks.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Different types of stem cells and their environments are key to skin repair and maintenance.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

KGF and activin are crucial for skin healing and repair.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

Correct skin biopsy techniques are crucial to avoid misdiagnosis of skin diseases.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.