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Vitamin D might help regulate insulin in the body, but taking Vitamin D supplements doesn't clearly prevent or improve type 2 diabetes. More research is needed.

Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.

Genetic variations greatly affect individual metabolism and can impact health and disease risk.

The document concludes that more multidisciplinary research is needed to understand and treat PCOS, a condition that significantly affects women's health and quality of life.

Honey and bee pollen can help reduce menopausal symptoms in breast cancer patients.

Testosterone's effects on COVID-19 are unclear and need more research.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

Women with PCOS may be more likely to have gum disease than healthy women.

The Polish medical societies have redefined metabolic syndrome and recommend lifestyle changes, certain medications, and possibly bariatric surgery for treatment. They also discuss managing related health conditions.

Using anabolic-androgenic steroids can harm men's reproductive health and increase the risk of heart problems and death.

More research is needed on the health effects of hormone therapy for transgender and nonbinary people.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

High Nesfatin-1 and low Vitamin D may increase blood pressure and heart rate in women with PCOS.

Cutaneous gene therapy could become a viable treatment for skin and hair disorders with improved vector development and gene expression control.

circRNA-1926 helps goat stem cells turn into hair follicles by affecting miR-148a/b-3p and CDK19.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Lindera aggregata has many beneficial compounds that can help prevent and manage diseases.

Type 1 diabetes often occurs with other autoimmune diseases, and personalized treatment based on genetics can improve outcomes.

Higher BMI and lower testosterone are linked to more aggressive prostate cancer.

Certain skin conditions in women are linked to higher risks of metabolic syndrome and type 2 diabetes due to hormone imbalances.

Testosterone therapy may slightly increase sexual desire in women with HSDD but lacks broad recommendation due to safety concerns and limited approval.

More high-quality research is needed to recommend flavonoids and saponins for clinical use.

Synthetic antioxidants are effective, cheap, and stable, with some like zinc and cholecalciferol reducing child and cancer deaths, but the safety of additives like BHA, BHT, TBHQ, and PEG needs more research.

Girls with PCOS have higher levels of certain androgens, which are linked to excess hair growth, but these androgens don't help diagnose PCOS.

Women with PCOS have more Bifidobacterium in their gut compared to those without PCOS.

Coffee berry extract may help slow skin aging and prevent hair loss.

Managing side effects of endocrine therapy is crucial to improve adherence and survival in breast cancer patients.

Anti-androgens can help manage some PCOS symptoms better than metformin but are not more effective than placebos or birth control pills for other symptoms.

Advancements in nanoformulations for CRISPR-Cas9 genome editing can respond to specific triggers for controlled gene editing, showing promise in treating incurable diseases, but challenges like precision and system design complexity still need to be addressed.

Isotretinoin therapy for acne can cause many reversible side effects, mainly mild skin conditions, and patient understanding of these effects can improve treatment adherence.