26 citations
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February 1998 in “Chemico-Biological Interactions” This review discusses recent molecular biology advances in the human phenol sulfotransferase gene family and reports no new results; the authors highlight its relevance for studies of endogenous and xenobiotic metabolism.
July 2024 in “Journal of Investigative Dermatology” This study found that systemic treatment with DS77754007, a KLK5 inhibitor, improved skin symptoms in a mouse model of Netherton Syndrome more effectively than certain antibody treatments, suggesting KLK5 inhibition as a promising therapeutic approach for this condition.
12 citations
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October 2020 in “Scientific Reports” In this study, Nec-1s was found to promote hair growth and may target necroptosis and the Wnt/β-catenin pathway for potential treatment of hair loss.
November 2019 in “Harper's Textbook of Pediatric Dermatology” This article reviews Netherton syndrome, focusing on its genetic basis, clinical presentation, and treatment options, and reports no clinical results; the authors mention potential benefits of targeted therapies and gene therapy.
48 citations
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March 2022 in “Nano Letters” This study suggests that sericin microneedles with antibacterial and directional traction functionalities may enhance infected wound healing by improving skin repair and inhibiting bacterial growth, indicating potential for clinical application.
January 2018 in “VCU Scholars Compass (Virginia Commonwealth University)” In this study using Xenopus laevis embryos, reduced levels of the desmosomal protein desmoplakin led to defects in epidermal and cardiac structures, suggesting its crucial role in tissue integrity.
91 citations
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May 2003 in “PubMed” This study found that neuroactive steroids, through their interaction with the sigma1 receptor, influence the acquisition of cocaine's rewarding effects in mice, suggesting a role in drug addiction vulnerability.
29 citations
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October 2004 in “Differentiation” Multiple mouse desmoglein 1 isoforms have distinct roles in skin and hair development.
May 2022 in “Research Square (Research Square)” This study found that nestin-expressing unipotent progenitor cells capable of differentiating into outer root sheath keratinocytes are present during hair follicle development and in adult hair follicles.
1 citations
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January 2012 In this study, the researchers cloned and analyzed the CRABP I gene in Inner Mongolian cashmere goats, finding its highest mRNA expression at 90 days in embryo skin compared to later stages.
12 citations
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July 2004 in “Molecular genetics and genomics” This study identifies a new mutation in the Scd1 gene in a strain of Kunming mice, causing skin and hair defects with the mildest impact among similar mutations.
49 citations
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January 2006 in “Developmental Dynamics” This research observed that the skeletal abnormalities in Noggin null mice varied based on genetic background, and identified haploinsufficiency leading to joint fusions, similar to human conditions associated with NOGGIN deficiency.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified intramembrane proteolysis as a key feature of Astrotactin2 maturation, providing insights into its role in planar cell polarity hair patterning.
September 2024 in “Genes” This study found that overexpressing CRABP1 in dermal papilla cells promotes their proliferation and influences key genes in the Wnt/β-catenin signaling pathway, which may offer insights into mechanisms controlling hair follicle development.
January 2025 in “Turkish Journal of Cerebrovascular Diseases” This case report details two consanguineous patients with cerebral autosomal recessive arteriopathy, both having the same HTRA1 gene mutation, but exhibiting different clinical presentations, including one with epileptic seizures and lobar hemorrhages—previously undocumented in this condition.
August 2019 in “Journal of Investigative Dermatology” This study found that the desmosomal protein desmoplakin is crucial for proper epidermal morphogenesis and radial intercalation in developing Xenopus embryos, affecting keratin organization and ectodermal structures.
September 2016 in “Journal of dermatological science” In this study, transplanted whisker follicles from ND-GFP mice aided spinal cord repair in injured mice, and surprisingly, also grew long hair shafts at the site of transplantation.
165 citations
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September 2001 in “Genes & development” This study found that Cutl1 mutant mice experienced retarded lung differentiation and abnormal hair follicle morphogenesis, indicating the vital role of CDP in lung development and hair follicle cell-lineage specification.
84 citations
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July 2003 in “European journal of biochemistry” This study found that mouse skin can produce and metabolize serotonin and N-acetylserotonin, with activity influenced by location, physiological skin status, cell type, and mouse strain.
September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study developed a biobased copolymer called SELP::KP, showing improved hair strength, elasticity, and conditioning properties while being a safer alternative to conventional chemical treatments, based on application to human hair in a laboratory setting.
64 citations
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April 1992 in “Differentiation” This study identified Sciellin, a new protein precursor to the cornified envelope in keratinocytes, with unique solubility properties hinting at its potential role in envelope assembly.
August 2023 in “Journal of Chromatographic Science” This study developed a reliable UHPLC-MS/MS method to measure flavonoids from Pinus massoniana needles in rat plasma for pharmacokinetics, aiding further research on their potential use in external preparations to prevent hair loss.
165 citations
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January 2006 in “Molecular Medicine” This review highlights the role of matriptase in epithelial differentiation and cancer, noting that unregulated matriptase expression can enhance cancer progression in animal models, but reports no new experimental data.
December 2025 in “PubMed” This study suggests that low molecular weight fish collagen peptide may promote hair follicle growth and regeneration, improving overall hair quality in mouse models.
6 citations
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February 2020 in “Journal of Natural Products” In this chemical investigation, cyclospongiaquinone 1 from the sponge Verongula cf. rigida showed strong steroid 5α-reductase inhibitory activity, comparable to that of finasteride.
80 citations
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December 1996 in “Pain” This study found that spinal strychnine enhances low threshold tactile responses in cat dorsal horn neurons, which may mirror pain states in humans that are less responsive to opioid treatments.
March 2023 in “Scientific reports” This study presents evidence that hair matrix progenitors and the enzyme Stearoyl CoA Desaturase 1 may play a role in maintaining the dermal papilla niche via autocrine Wnt and paracrine Hedgehog signaling in mice.
1 citations
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April 2023 in “Science Advances” This study found that sustained ERK activity during tissue regeneration in spiny mice is linked to fibroblast growth factor and ErbB signaling, while inhibiting ERK shifted regeneration toward scarring.
20 citations
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November 2019 in “Stem Cells” This study found that deleting the Hes1 gene disrupts hair regeneration by delaying anagen initiation and shortening the anagen phase, suggesting it's crucial for maintaining hair cycle homeostasis.
2 citations
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July 1968 in “Experimental Biology and Medicine” In this study, cystaselenonine treatment in mice resulted in hair loss limited to older growing hairs and delayed regrowth, while also causing temporary weight loss.