126 citations
,
January 1987 in “Current topics in developmental biology/Current Topics in Developmental Biology” Different keratin proteins are expressed in various epithelial cells at different stages, affecting cell structure and function.
97 citations
,
March 2010 in “The American Journal of Human Genetics” A mutation in the KRT74 gene causes tightly curled hair.
5 citations
,
October 2023 in “Forests” In this study, researchers assessed the genetic diversity of 101 Ginkgo biloba individuals using EST-SSR markers and concluded that there is a high level of genetic diversity in Ginkgo populations, facilitating the construction of a core germplasm collection for breeding purposes.
December 2004 in “SUNScholar (Stellenbosch University)” This study suggests that identified polymorphisms may serve as markers for assessing an individual's risk of developing prostate cancer.
418 citations
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January 2018 in “Journal of Investigative Dermatology” This study identified at least four distinct fibroblast populations in adult human skin, each with unique functional properties, suggesting potential therapeutic applications for wound healing and fibrosis-related diseases.
72 citations
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August 2014 in “Genome Biology and Evolution” This study found that the differential expression of α- and β-keratin genes in feathers may explain their morphological and structural diversity, highlighting the chicken as a model for studying keratin-related diseases.
62 citations
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August 2006 in “Journal of Chromatography B” This article reviews the challenges in studying keratin proteins and emphasizes the potential of modern proteomic techniques to advance their research, but it reports no new findings.
48 citations
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November 2002 in “Journal of biological chemistry/The Journal of biological chemistry” In this study, researchers found that size polymorphisms in certain hKAP1 genes are linked to the hKAP1.1B and hKAP1.3 genes, arising from intragenic deletions and duplications in Japanese and Caucasian populations.
36 citations
,
July 2020 in “American Journal of Infection Control” This study observed that males aged 60 to 79 were admitted and died from COVID-19 more frequently than females, and Latin Americans were more often admitted to the ICU.
29 citations
,
November 2022 in “Nature Medicine” This study identified thousands of variant-metabolite associations in the human plasma metabolome, offering insights into the genetic bases of metabolism and potential adverse drug effects.
29 citations
,
January 2021 in “G3 Genes Genomes Genetics” This study identified a 195 bp duplication in crested chickens that causes large crest feathers and can be associated with cerebral hernia in some breeds, but not all.
10 citations
,
November 2024 in “Animals” This review examines the genetic challenges in improving wool and cashmere fibers, emphasizing the need for further research on wool keratins and keratin-associated proteins to enhance fiber characteristics.
9 citations
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June 2024 in “Genes” This study examined the Spanish Merino breed's wool quality, identifying 74 genetic variants linked to key wool traits like fiber diameter and staple length, which could help restore the breed's potential for producing high-quality wool.
9 citations
,
March 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that the maintenance and morphogenesis of skin appendages rely on both the dose and duration of ectodysplasin signaling.
4 citations
,
June 2024 in “Animals” This review examines the genetic factors influencing coat color in horses and donkeys, highlighting key genes like MC1R, TYR, MITF, ASIP, and KIT, and discusses implications for selective breeding and the relationship between coat color and specific equine diseases.
2 citations
,
May 2023 in “Veterinary Pathology” This article outlines methods to study the skin and its molecular traits, focusing on interpretation and techniques applicable to mouse models, including diverse assays and approaches like electron microscopy and large-scale lipid analyses.
1 citations
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September 2024 in “Animals” In this study, researchers identified six unique genetic variants of a sheep gene, KRTAP19-3, with specific variants linked to changes in wool fibre traits, such as increased fibre diameter variability, suggesting these genetic differences affect wool characteristics in Chinese Tan sheep.
25 citations
,
April 2019 in “Animals” In this study, KRTAP28-1 variants were associated with wool fibre diameter in sheep, suggesting potential as a gene marker for reducing fibre diameter.
106 citations
,
June 2009 in “BMC Genomics” This study identified specific gene expression profiles during the intestinal regeneration of sea cucumbers, highlighting potential novel genes and advancing the understanding of regenerative biology in echinoderms.
95 citations
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March 2009 in “Differentiation” Gene expression in wool follicles changes with growth cycles, offering insights into wool and human hair growth.
18 citations
,
May 2023 in “Science Advances” In this study, transiently activating the sonic hedgehog signaling pathway in chickens transformed reticulate scales on the feet into feathers comparable to body feathers, without ongoing treatment, suggesting this pathway affects the diversity of bird skin appendages.
17 citations
,
October 1997 in “Australian Journal of Agricultural Research” This study observed that nutritional stress is likely responsible for changes in Merino sheep follicle morphology in Mediterranean environments, affecting staple strength and possibly requiring targeted management strategies.
5 citations
,
January 2021 in “PeerJ” This study observed that high levels of immunoreactive cortisol in the tail hair of captive Asian elephants were often associated with stressful or distinct behavioral events, suggesting its potential for reconstructing their physiological history.
2 citations
,
March 2023 in “BMC ecology and evolution” This study suggests that some keratin-associated proteins with antecedents found in non-haired animals may have roles beyond hair characteristics, possibly contributing to the evolution of hair follicles.
In this study, Fgf20 was found to trigger movement and morphogenesis in dermal fibroblasts, facilitating dermal condensate formation essential for hair follicle development.
October 2023 in “Journal of Molecular Liquids” This study demonstrated that imidazole-based ionic liquids, particularly [Emim]DEP, effectively dissolved yak hair keratin, maintaining its structure better than other tested solvents, and also performed well on human hair and goat wool, with consistent performance even after five recycling cycles.
In this study, researchers successfully cloned the KAP24.1 gene from sheep to analyze its expression in skin and hair follicles, finding that Mountain-type Hetian sheep showed the highest levels of expression and that androgen concentration significantly influenced KAP24.1 protein expression.
April 2023 in “Anatomy Physiology & Biochemistry International Journal” In this study, researchers identified specific SNPs associated with polycystic ovarian syndrome in women from Karnataka, which could improve understanding of genetic mechanisms and aid in future diagnosis and treatment efforts.
February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, the researchers found that KAP3.1, KRTAP 8-1, and KRTAP 24-1 genes positively correlated with the growth cycle of cashmere in Inner Mongolia goats, aligning with the observed hair cycle phases.
This study found that fibroblast growth factor 20 (Fgf20) orchestrates the movement and behavior of dermal fibroblasts, directing their formation into dermal condensates during hair follicle development in mice.