Decision Letter: Hair Follicle Dermal Condensation Forms Via FGF20 Primed Cell Cycle Exit, Cell Motility, and Aggregation
April 2018
TLDR Fgf20 is crucial for hair follicle formation by influencing cell movement and growth.
The study investigated the role of Fgf20 in the formation of hair follicle dermal condensation, focusing on cell cycle exit, cell motility, and aggregation. It found that mesenchymal cells migrate directionally, exit the cell cycle, and express dermal condensate marker genes to form the follicular papilla, with Fgf20 playing a crucial role in these processes. However, the sequence of events, particularly whether cells migrate before or after exiting the cell cycle and expressing Sox2, remained unresolved. The research confirmed that the effects observed were due to FGF signaling inhibition, but further research was needed to clarify some aspects. Despite technical challenges, the study provided new insights into hair follicle development, highlighting that Fgf20 increased cell migration speed in vitro, though its in vivo effects were unclear.
