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research Decision letter: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

April 2018

This study found that fibroblast growth factor 20 (Fgf20) orchestrates the movement and behavior of dermal fibroblasts, directing their formation into dermal condensates during hair follicle development in mice.

research Author response: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

1 citations , July 2018

In this study, Fgf20 was found to trigger movement and morphogenesis in dermal fibroblasts, facilitating dermal condensate formation essential for hair follicle development.

research The Historical Studies Underpinning the Concept of Hair Follicle Neogenesis

January 2022 in “Springer eBooks”

This review discusses the potential of the hair follicle dermis to direct hair development and explores concepts related to hair growth and androgenetic alopecia, without reporting new clinical results.

research Dynamic expression patterns of tenascin, proteoglycans, and cell adhesion molecules during human hair follicle morphogenesis

67 citations , February 1994 in “Developmental dynamics”

This study analyzed the distribution of adhesion molecules and extracellular matrix components in human fetal skin, suggesting their roles in hair follicle development.

research Keratin is not only a Structural Protein in Hair: Keratin-mediated Hair Growth

November 2020 in “Research Square (Research Square)”

In a mouse model, this study found that intradermal keratin injection stimulated hair growth and suggested its potential use for treating hair loss by promoting hair regeneration.

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Community Join

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community Hair follicle dermal papilla exosomes

2 upvotes 1 year ago

The conversation discusses using hair follicle dermal papilla exosomes for hair loss treatment. It inquires about purchasing options for this treatment.

community Hair transplants and PP405 - Irregular density concern

18 upvotes 6 months ago

The conversation discusses concerns about getting a hair transplant with the potential release of a new treatment, PP405, which may regrow dormant hair follicles. The user is currently using Minoxidil, Derma, and Keto but is waiting to start finasteride or dutasteride.

community 3mm microneedling with derma-stamp?

1 year ago

The conversation discusses experimenting with microneedling for hair loss, with OP considering using a 3mm derma-stamp. Other users advise against going beyond 1.5mm to avoid damage.

community How do you prevent infection with derma needling / derma stamping?

1 upvotes 1 year ago

The conversation discusses preventing infection from derma stamping for hair loss treatment, with suggestions to reduce needle depth and consider alternatives like tretinoin. The user experienced irritation possibly from zinc chloride and stopped using the shampoo and derma stamping.

community Close Up of 1.5 months progress. Minox + 0.5mm Derma Stamp + Caffeine Serum

in Progress Pictures 2 upvotes 4 months ago

The conversation discusses hair loss treatment progress using Minoxidil, a 0.5mm derma stamp, and caffeine serum, with additional use of rosemary, peppermint, and olive oil. The user is avoiding DHT blockers like Finasteride due to potential interference with other medications.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn SCUBE3

a signaling molecule from dermal papilla cells being actively researched

How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

learn Platelet-Rich Plasma

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

learn Niacinamide

How does Niacinamide support the hair follicle’s nutrition? Niacinamide nourishes hair follicles by boosting energy production and supporting antioxidant defenses.

learn oleic acid

How does Oleic Acid support hair follicle strength and growth? Oleic acid strengthens hair follicles by enhancing hydration and reducing inflammation.

learn zinc PCA

Why is zinc important for preventing hair loss and supporting hair follicle function? Zinc is crucial for hair follicle health, supporting growth and repair processes.

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Clinics

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All 38 clinic results →

Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas