TLDR Different androgen concentrations affect wool-related gene expression differently in Hetian and Karakul sheep breeds.
The study successfully cloned the complete CDS region of the KAP24.1 gene from plain-type Hetian sheep, mountain-type Hetian sheep, and Karakul sheep, with a length of 759 bp encoding 252 amino acids. The KAP24.1 gene was found to be an unstable protein. Sequence similarity and phylogenetic tree analysis indicated that these sheep have the closest genetic relationship with goats and the farthest with Canadian deer. Additionally, the eukaryotic recombinant expression vector of the KAP24.1 gene was successfully constructed, providing a basis for further research on the gene's role in determining wool traits.
10 citations,
November 2021 in “International journal of molecular sciences” Sheep and goat hair fibers are complex due to keratin-associated proteins, which are important for fiber properties and growth.
2 citations,
April 2021 in “FEBS open bio” Human hair keratins K85 and K35 create unique filament patterns important for early hair formation.
98 citations,
May 2016 in “Genes” Understanding wool keratin-associated proteins in sheep can help improve wool quality through selective breeding.
48 citations,
February 2010 in “Molecular biology reports” KAP7.1 and KAP8.2 genes are crucial for cashmere quality in goats.
51 citations,
January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.
KRTAP6 genes affect wool quality in sheep.
April 2003 in “Experimental Dermatology” The workshop highlighted the genetic links and psychological impacts of hair loss and skin disorders.
107 citations,
December 2013 in “International Journal of Dermatology” The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.
13 citations,
September 2021 in “Current Issues in Molecular Biology” Dexpanthenol helps human hair follicle cells grow by preventing aging and death, and by supporting growth signals.
September 2023 in “Biomedical Optics Express” New imaging techniques show testosterone delays hair growth and shrinks follicles in mice, but have limited depth for viewing.
