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    Glossary Secreted Frizzled-Related Protein 2

    regulates cell signaling pathways affecting hair follicle development

    Secreted Frizzled-Related Protein 2 (SFRP2) is a protein that plays a role in regulating cell signaling pathways, particularly the Wnt signaling pathway, which is crucial for cell growth, differentiation, and development. In the context of hair biology, SFRP2 can influence hair follicle development and cycling, potentially impacting conditions like alopecia.

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    1. Secreted Frizzled‐Related Protein 2 ( SFRP2 ) Induces Follistatin‐Like 1 ( FSTL1 ) to Regulate Dihydrotestosterone ( DHT )‐Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence Aging Cell · 2026
    2. Peer Review #2 of "Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles (v0.1)" 2019
    3. Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle Stem Cells International · 2017 · 8 citations
    4. Peer Review #1 of "Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles (v0.1)" 2019
    5. Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles PeerJ · 2019 · 7 citations
    6. Follistatin and secreted frizzled-related protein 1, OVO homolog-like 1-regulated genes, are important for hair follicle neogenesis Experimental Dermatology · 2015 · 4 citations
    7. Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio Journal of the Pakistan Medical Association · 2024 · 2 citations
    8. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    9. SFRP2 augments Wnt/β-catenin signalling in cultured dermal papilla cells Experimental Dermatology · 2016 · 17 citations
    10. Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin International journal of molecular sciences · 2024
    11. Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development Molecular Biology of the Cell · 2018 · 25 citations
    12. Is SFRP-4 an early potential biomarker related to diabetes and hypertension, in patients with androgenic alopecia? Endocrine Abstracts · 2018
    13. Clinical Snippets Journal of Investigative Dermatology · 2016
    14. Clinical Snippets Experimental Dermatology · 2016
    15. The role of SFRP1 in human dermal papilla cell growth and its potential molecular mechanisms as a target in regenerative therapy Regenerative Therapy · 2024
    16. Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration Advanced functional materials · 2020 · 220 citations
    17. Wnt signaling in skin organogenesis Organogenesis · 2008 · 72 citations
    18. Dermal niche signaling and epidermal stem cells Advances in stem cells and their niches · 2019
    19. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    20. Stromal Cells of the Human Postmenopausal Ovary Display a Distinctive Biochemical and Molecular Phenotype Obstetrical & Gynecological Survey · 2003
    21. UNCONVENTIONAL PROTEIN SECRETION OF KERATIN 75 BY AMELOBLASTS IN VIVO D-Scholarship@Pitt (University of Pittsburgh) · 2018
    22. Integrated analysis of miRNAs and mRNA profiling reveals the potential roles of miRNAs in sheep hair follicle development BMC genomics · 2022 · 5 citations
    23. Molecular Conversations and the Development of the Hair Follicle and Basal Cell Carcinoma Cancer Prevention Research · 2010 · 21 citations
    24. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014 · 223 citations
    25. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Genes & Diseases · 2019 · 31 citations
    26. The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled Journal of Investigative Dermatology · 2017 · 8 citations
    27. Expression of Signaling Components in Embryonic Eyelid Epithelium PloS one · 2014 · 5 citations
    28. Genome-Wide Identification and Characterization of the Wnt Gene Family in Donkey (Equus asinus): Phylogenetic Analysis and Expression Profiling Biology · 2026
    29. Hoxc13 polyglycine repeat gain-of-function drives mammalian integument evolution by altering targeted genes and interactions Research Square · 2026
    30. <i>Malva verticillata</i>seed extracts upregulate the Wnt pathway in human dermal papilla cells International Journal of Cosmetic Science · 2015 · 25 citations