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    Glossary Sebaceous Gland

    small skin gland producing oily sebum for lubrication

    A sebaceous gland, also known as an oil gland, is a small gland in the skin that produces sebum, an oily substance that helps to lubricate and protect the skin and hair. These glands are typically found in high concentrations on the face and scalp and are connected to hair follicles, releasing sebum through the hair follicle to the surface of the skin.

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    1. 724 MPZL3 functions as a negative regulator of sebaceous gland size and sebocyte proliferation 2022
    2. Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice Experimental Dermatology · 2013 · 22 citations
    3. 1434 Epithelially derived MPZL3 negatively regulates murine and human sebaceous gland size and sebocyte proliferation Journal of Investigative Dermatology · 2023
    4. 548 Deletion of Myelin Protein Zero-like 3 increases sebaceous gland size and sebocyte proliferation but reduces skin adipose depots: Can MPZL3 inhibition promote excessive loss of lipids via sebum hypersecretion? Journal of Investigative Dermatology · 2022
    5. A cross-sectional observational study showing sebaceous glands differences between psoriatic alopecia and alopecia areata JAAD International · 2024 · 2 citations
    6. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size Molecular Cell · 2018 · 90 citations
    7. Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity Journal of Investigative Dermatology · 1995 · 37 citations
    8. Marked Reduction of the Number and Individual Volume of Sebaceous Glands in Psoriatic Lesions Dermatology · 2016 · 10 citations
    9. Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands 2013 · 25 citations
    10. Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: A treatment strategy for acne Journal of Dermatology · 2010 · 8 citations
    11. Development of a nude mouse model to study human sebaceous gland physiology and pathophysiology. Journal of Clinical Investigation · 1984 · 25 citations
    12. A morphometric and histologic study of the scalp in psoriasis. Paradoxical sebaceous gland atrophy and decreased hair shaft diameters without alopecia. PubMed · 1989 · 15 citations
    13. The Microanatomy of Human Skin in Aging bioRxiv (Cold Spring Harbor Laboratory) · 2024 · 5 citations
    14. Distinctive or critical histological features and associated diseases Informa Healthcare eBooks · 2012
    15. Penetration and Distribution in Human Skin Focusing on the Hair Follicle CRC Press eBooks · 2005 · 1 citations
    16. Changes in the sebaceous gland in patients with male pattern hair loss (androgenic alopecia) Journal of Cosmetic Dermatology · 2015 · 14 citations
    17. 574 Murine sebaceous gland homeostasis requires intact cutaneous innervation in a hair cycle-dependent context 2019
    18. Acne and sebaceous gland function Clinics in dermatology · 2004 · 463 citations
    19. Epigen Transgenic Mice Develop Enlarged Sebaceous Glands Journal of Investigative Dermatology · 2009 · 33 citations
    20. Adrenal steroid precursors exert potent androgenic action in the hamster sebaceous glands of flank organs and ears. Endocrinology · 1996 · 8 citations
    21. An updated review of the sebaceous gland and its role in health and diseases Part 2: Pathophysiological clinical disorders of sebaceous glands Dermatologic Therapy · 2021 · 7 citations
    22. Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation Frontiers in Pharmacology · 2024 · 3 citations
    23. Sebaceous gland loss and inflammation in scarring alopecia: A potential role in pathogenesis Journal of The American Academy of Dermatology · 2011 · 37 citations
    24. Cidea Control of Lipid Storage and Secretion in Mouse and Human Sebaceous Glands Molecular and Cellular Biology · 2014 · 36 citations
    25. Lrig1 Expression in Human Sebaceous Gland Tumors Dermatopathology · 2016 · 3 citations
    26. Preservation of sebaceous glands and peroxisome proliferator-activated receptor gamma expression in central centrifugal cicatricial alopecia Journal of The American Academy of Dermatology · 2018 · 1 citations
    27. Single-cell analysis of 2,3,7,8-tetrachlorodibenzo- <i>p</i> -dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes <i>Ahr</i> -dependent seboatrophy with elevated expression of infundibular <i>Blimp1</i> bioRxiv (Cold Spring Harbor Laboratory) · 2026
    28. Gate keeping the sebaceous gland bioRxiv (Cold Spring Harbor Laboratory) · 2023
    29. The disrupted balance between hair follicles and sebaceous glands in<i>Hoxc13</i>‐ablated rabbits ˜The œFASEB journal · 2018 · 18 citations
    30. Androgens Affect the Activity of Human Sebocytes in Culture in a Manner Dependent on the Localization of the Sebaceous Glands and Their Effect Is Antagonized by Spironolactone Skin Pharmacology and Physiology · 1994 · 40 citations