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The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.

Cicatricial alopecia may be caused by immune attacks on hair follicles, gland issues, or stem cell damage.

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

The Hairless gene is crucial for hair cell development, affecting whether skin cells become hair or skin and oil gland cells.

A new EDA gene mutation was found in a Chinese family with a specific skin disorder.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.

Testosterone and some of its forms can strongly stimulate oil gland growth in skin.

Isotretinoin shrinks sebaceous glands without affecting hair or skin color, unlike etretinate.

Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.

Sebaceous glands play a key role in skin health and conditions like acne.

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Eating high-glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

The human sebocyte culture model has improved understanding of oily skin and acne, and how they can be treated.

Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

Cathepsin L is essential for normal hair growth and development.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Pregnancy can cause skin pigmentation, stretch marks, and changes in hair, nails, and sweat glands, with most resolving after birth.

Mutant mice help researchers understand hair growth and related genetic factors.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.