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This case report details a Taiwanese woman with scleredema adultorum and diabetes mellitus experiencing loss of eccrine glands, which led to frequent heat strokes and anhidrosis despite treatment.

This study found that microRNA levels in hair shafts were significantly decreased in scleroderma patients compared to normal subjects, suggesting they may serve as effective biomarkers.

This report describes almost complete resolution of calcinosis and healing of associated ulcers in an 83-year-old woman with localized scleroderma after repeated intralesional steroid injections.

In this study, hair shaft miR-29a levels were significantly lower in scleroderma patients than in controls, suggesting that hair microRNAs could serve as independent biomarkers for the disease.

This case report describes a rare instance of double-lined frontoparietal scleroderma en coup de sabre and suggests a genetic basis involving postzygotic mosaicism.

This study reports that six women developed scleroderma while taking L-tryptophan and showed improvement after stopping the supplement and/or starting corticosteroid therapy.

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In this case study, calcitriol treatment led to improvement in scleroderma symptoms and partial hair regrowth in a 20-year-old girl after other treatments had failed.

Researchers created a new mouse model for studying scleroderma.

This case report describes a 30-year-old female with overlap syndrome involving systemic lupus erythematosus and scleroderma, where individualized treatment significantly reduced her pericardial effusion.

This study established a murine chronic graft-versus-host disease model with scleroderma features, showing typical skin changes and cellular infiltrates associated with the condition.

This study concluded that etretinate showed only moderate effects in treating lichen sclerosus and localized scleroderma, with some patients experiencing clearing but others having no resolution or lesion progression.

In this study, methotrexate effectively treated juvenile localized scleroderma in most cases, with few patients showing resistance and no identifiable profile for these resistant individuals.

This case report discusses a rare occurrence of systemic sclerosis with lupus erythematosus panniculitis in a Japanese patient and highlights hydroxychloroquine as a potential treatment, noting a dramatic improvement.

A patient had both chronic lupus and systemic scleroderma, requiring careful treatment to manage symptoms.

This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.

This study found that Annexin A5 significantly reduced fibrosis and inflammation in both preventive and therapeutic contexts in a bleomycin-induced localized scleroderma mouse model, demonstrating its potential anti-fibrotic and anti-inflammatory effects for treating fibrotic diseases.

This study found that ablative fractional carbon dioxide laser treatment improved skin fibrosis, reduced skin hardening, and enhanced hair follicle growth in localized scleroderma patients, with significant improvements across several clinical measures and no severe adverse effects observed.

In this case report, researchers describe a 17-year-old African male with an overlapping condition of juvenile dermatomyositis and systemic scleroderma, highlighting the importance of thorough history-taking and physical examination for accurate diagnosis and suggesting early referral to a pediatric rheumatologist to prevent severe outcomes.

This study found that autologous fat grafting for facial asymmetry in progressive hemifacial atrophy and linear scleroderma showed similar outcomes regardless of whether performed during the active or stable phase of the disease, suggesting it may be a safe option in the active phase.

This case report describes a cat with localized scleroderma (morphea-like) that did not show clinical resolution or spontaneous remission after treatment, differing from previously documented cases.

Hyaluronic acid injections can improve mouth opening and quality of life in scleroderma patients.

This pilot study suggests that a new preparation of platelet-rich plasma gel may improve symptoms and tissue regeneration in patients with en coup de sabre scleroderma, though further trials are needed to clarify its role.

The authors developed a severe mouse model of chronic graft-versus-host disease and reported that rapamycin treatment improved survival compared to placebo, potentially by promoting regulatory T cell expansion.

This study concluded that mucocutaneous symptoms can assist in diagnosing diabetes mellitus and its complications, highlighting the potential for dermatologists to detect related systemic issues early in patients.

This review discusses the skin manifestations of endocrine diseases and reports no new clinical findings, emphasizing the importance of recognizing these signs for early diagnosis.

Diabetes can cause a variety of skin disorders, some of which may signal more serious health issues.

In this review, the authors detailed the clinical, trichoscopic, and histopathological features of hair disorders linked to autoimmune diseases, highlighting the role of dermatologists in identifying possible underlying autoimmune conditions in patients presenting with hair loss.

This case report details a woman with eosinophilia-myalgia syndrome associated with L-tryptophan ingestion, highlighting skin lesions with abundant dermal mucin.

This review discusses the potential of targeting the endocannabinoid system for treating skin disorders and reports no new clinical results, highlighting the need for further research.