A Filipino With Systemic Lupus Erythematosus-Scleroderma Overlap Syndrome

September 2015 in “ Philippine Journal of Internal Medicine ”

Kristian Anteolin D Punzalan, Patrick Y Siy, Engelbert Simon Perillo, Lorielle Marie E.S Galvez, Sandra Tankeh-Torres, Philip U Chua

systemic lupus erythematosus scleroderma erythematous macules skin tightening hair loss prednisone azathioprine

TLDR Recognizing and treating overlap syndrome in connective tissue diseases is crucial.

The document described a case of a 30-year-old Filipino female with systemic lupus erythematosus-scleroderma overlap syndrome, presenting with symptoms such as erythematous macules, skin tightening, hair loss, anemia, and ulcerating wounds. She also experienced generalized weakness, pulmonary hypertension, and a large pericardial effusion, which improved with prednisone and azathioprine treatment. The case highlighted the importance of recognizing overlap syndrome in patients with symptoms of multiple connective tissue diseases and emphasized that treatment should be tailored to the specific diseases involved.

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