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360-390 / 1000+ resultsresearch A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb
research ROR2 regulates self-renewal and maintenance of hair follicle stem cells
In this study, researchers discovered that ROR2, a Wnt receptor, plays a crucial role in regulating hair follicle stem cell self-renewal and maintenance, compensating for the absence of β-catenin.
research Angiogenic factor-driven improvement of refractory thin endometrium with autologous platelet-rich plasma intrauterine infusion in frozen embryo transfer cycles
This study found that intrauterine PRP infusion is a safe and effective treatment for patients with refractory thin endometrium and implantation failures, with the improvement primarily driven by the angiogenic cytokines in PRP.
research Analysis of Histology and Long Noncoding RNAs Involved in the Rabbit Hair Follicle Density using RNA Sequencing
This study found that Wan strain Angora rabbits with high wool production had higher hair follicle density and identified five long noncoding RNAs as potential regulators of this trait.
research Analysis of Skin Regeneration and Barrier-Improvement Efficacy of Polydeoxyribonucleotide Isolated from Panax Ginseng (C.A. Mey.) Adventitious Root
In laboratory and artificial skin model experiments, this study found that plant-derived PDRN from Korean ginseng effectively promoted skin cell regeneration and strengthened the skin barrier, suggesting a sustainable alternative to animal-derived PDRN.
research Minimum requirements for reporting clinical trials evaluating the therapeutic potential of platelet-rich plasma
This letter comments on a randomized controlled trial by Shapiro et al that found no significant benefits of platelet-rich plasma compared to placebo for male androgenetic alopecia, highlighting issues with PRP protocol variations.
research PLATELET RICH PLASMA THERAPY FOR SKIN REJUVENATION
This article discusses the popularity and mechanisms of Platelet Rich Plasma therapy for skin rejuvenation and hair loss, but it reports no new clinical results.
research Expression of the RORα gene in Inner Mongolian cashmere goat hair follicles
This study suggests melatonin may promote cashmere growth in Inner Mongolian cashmere goats through the nuclear receptor RORα, with a noted mRNA expression difference in December compared to other months.
research ELL Facilitates RNA Polymerase II–Mediated Transcription of Human Epidermal Proliferation Genes
This study reported that ELL is crucial for maintaining the proliferative capacity of the basal layer in human epidermal keratinocytes by stabilizing RNA polymerase II at the transcription start site.
research QR 678 & QR678 Neo Vs PRP—A randomised, comparative, prospective study
In this study, intradermal injections of QR678 were found to significantly reduce hair fall in men with androgenetic alopecia over 6 months, with superior improvements in hair density and thickness compared to PRP.
research 197 A novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair
This case report identifies a novel LIPH gene mutation linked to autosomal recessive woolly hair/hypotrichosis in a Japanese boy, expanding the spectrum of known mutations associated with this condition.
research Efficacy and safety of a novel anti‐HER2 therapeutic antibody RC48 in patients with HER2‐overexpressing, locally advanced or metastatic gastric or gastroesophageal junction cancer: a single‐arm phase II study
This study found that the novel anti-HER2 antibody RC48 demonstrated promising activity and manageable safety in patients with HER2-overexpressing, advanced gastric or gastroesophageal junction cancer after at least two prior chemotherapy lines.
research Structural Abnormalities in the Hair of a Patient with a Novel Ribosomopathy
This study characterized hair from a patient with a ribosomopathy and identified distinct differences, including reduced hair thickness and lipid content, compared to family members.
research Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits
This study observed that genetic variation in the ovine KRTAP22-1 gene is linked to increased wool yield and decreased fiber curvature in sheep, indicating its potential use in breeding programs.
research PRP in Hair Restoration
This review discusses platelet-rich plasma therapy for hair restoration and reports no new clinical results.
research A propòsit de la possible intervenció de Reinard des Fonoll en la construcció de l'església arxiprestal de Morella
In this study, researchers identified wound-induced gene expression programs during regeneration initiation in planarians, highlighting the importance of the runt-1 gene and other conserved genes in the process.
research A Girl with a Novel Splice Site Mutation in VDR Supports the Role of a Ligand-Independent VDR Function on Hair Cycling
In this case study, a girl with hereditary vitamin D resistant rickets had a novel mutation in the VDR gene that affected hair cycling without causing total alopecia, suggesting ligand-independent VDR function in hair cycling.
research Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin
This study identified key long non-coding RNAs and mRNAs involved in primary wool follicle induction in carpet wool sheep, emphasizing their roles in hair follicle development and skin processes.
research Clinical Snippets
R-spondin2 may help treat hair loss, gene differences could explain baldness, a peptide's regulation is linked to psoriasis, B-defensin gene copies may affect a skin condition's risk and severity, and potential markers and targets for alopecia areata were identified.
research A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing
This study mapped genomic copy number variation in Chinese fine-wool sheep, identifying genes involved in sensory perception, nutrient metabolism, growth, and development, and highlighting significant selection on the RXFP2 gene.
research 850 After skin wounding, noncoding dsRNA coordinates prostaglandins and WNT7b to promote regeneration
This study found that TLR3-mediated damage sensing can stimulate prostaglandin and Wnt pathways, potentially coordinating hair follicle regeneration in mice with large skin wounds.
research Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide
research Longitudinal biomarker trajectories accompanying trichoscopic change after PRP-based regimens for alopecia: a complementary multi-marker analysis of a real-world cohort.
This study observed that while hair density generally increased after PRP-based treatments for nonscarring alopecia, the extent of improvement and associated biomarker changes varied widely among individuals.
research Platelet-rich plasma in dermatology and aesthetic medicine
This review highlights the positive effects of platelet-rich plasma in aesthetic and regenerative medicine, particularly for skin rejuvenation, anti-aging, hair reconstruction, and wound healing, but it reports no new clinical results.
research The Retinoic-Acid-Related Orphan Receptor Alpha May Be Highly Involved in the Regulation of Seasonal Hair Molting
This study found that melatonin may enhance hair follicle stem cell viability by downregulating the nuclear receptor RORA, which otherwise inhibits cell proliferation and promotes apoptosis.
research Analysis of histology and long noncoding RNAs involved in the rabbit hair follicle density using RNA sequencing
This study found that Wan strain Angora rabbits with high wool production exhibited higher hair follicle density and identified long noncoding RNAs that may regulate this trait.
research Keratin 79 is a PPARA target that is highly expressed by liver damage
This study found that hepatic KRT79 expression is regulated by PPARA and is significantly associated with liver stress, suggesting it may serve as a diagnostic marker for liver diseases.
research Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex
Repetin is a protein involved in skin and hair development, binding calcium and compensating for other proteins when needed.
research Platelet-rich plasma (PRP): history of the platelets� concentrates and current applications in medicine
This review traces the development and application of Platelet-rich Plasma in regenerative medicine, emphasizing its role in tissue healing and bone regeneration, but reports no new clinical results.