About the Possible Intervention of Reinard des Fonoll in the Construction of the Archpriestal Church of Morella

    January 1969 in “ Santes Creus: Boletín del Archivo Bibliográfico de Santes Creus ”
    Josep M. Recasens i Comes
    TLDR Planarians regenerate using conserved gene expression mechanisms, with runt-1 crucial for cell type specification.
    The study investigated the gene activation program in planarians during regeneration initiation, identifying two waves of wound-induced gene expression in differentiated tissues. The first wave involved conserved immediate early genes, while the second wave included conserved patterning factors essential for regeneration. The research highlighted the role of neoblasts, including pluripotent stem cells, in regeneration, with the runt-1 gene being crucial for cell type specification. Wound-induced gene expression in neoblasts required SRF and sos-1. The findings suggested that the mechanisms of wound-induced gene expression in planarians are conserved across metazoans, providing insights into wound signaling and regeneration initiation.
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