research Ablation of Alkaline Phosphatase in Human Dermal Papilla Spheroid Impairs Hair Follicle Induction
Removing alkaline phosphatase from human skin cells hinders the creation of new hair follicles.
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research Clinical Snippets: Research Findings in Dermatology
New findings suggest potential treatments for melanoma, hyperpigmentation, hair defects, and multiple sclerosis, and show skin microbiome changes don't cause atopic dermatitis.
research Clinical Snippets: Insights into Dermatological Studies
Some cells may slow melanoma growth, a protein could affect skin pigmentation, a gene-silencing method might treat hair defects, skin bacteria changes likely result from eczema, and a defensin protein could help treat multiple sclerosis.
research Cell Death Functions in Hair Follicle Regeneration
Proper cell death regulation is crucial for normal hair follicle regeneration and skin remodeling.
research Efficacy of Asymmetric siRNA Targeting Androgen Receptor for the Treatment of Androgenetic Alopecia
cp-asiAR may effectively treat hair loss by targeting androgen receptors.
research Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism
Skin bacteria help hair regrow by boosting cell metabolism.
research Molecular Regulation and Cellular Heterogeneity in Skin Repair and Hair Follicle Regeneration
Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.
research Single Cell Analysis of Transcriptome and Open Chromatin Reveals the Dynamics of Hair Follicle Stem Cell Aging
Hair follicle stem cells change states with age, affecting hair growth and aging.
research The Potential Role of hsa_circ_0001079 in Androgenetic Alopecia via Sponging hsa-miR-136-5p
hsa_circ_0001079 may help diagnose and treat hair loss.
research Single-Cell Transcriptomics Reveals Distinct Molecular Programs in Folliculotropic Mycosis Fungoides
Folliculotropic mycosis fungoides has unique molecular features and cell interactions that could guide targeted therapy.
research A Perspective on RNAi-Based Biopesticides
RNAi-based biopesticides could be safe and effective for pest control with careful development and risk assessment.
research LncRNA PlncRNA-1 Regulates Proliferation and Differentiation of Hair Follicle Stem Cells Through TGF-β1-Mediated Wnt/β-Catenin Signal Pathway
PlncRNA-1 helps hair follicle stem cells grow and develop by controlling a specific cell signaling pathway.
research LncRNA-PCAT1 Maintains Characteristics of Dermal Papilla Cells and Promotes Hair Follicle Regeneration by Regulating miR-329/Wnt10b Axis
PCAT1 helps hair growth by controlling miR-329/Wnt10b.
research Frontal Fibrosing Alopecia Is Associated With Dysregulation of Cholesterol Biosynthesis Pathways, Fibrosis, and Mast Cells
Frontal Fibrosing Alopecia involves disrupted cholesterol pathways, fibrosis, and increased mast cells.
research Identification of Potential Biomarkers for Diagnosis of Patients with Methamphetamine Use Disorder
Gene expression in hair follicles can help diagnose methamphetamine use disorder.
research Exploring Human Skin Aging at the Single-Cell Level
Middle-aged skin shows aging signs, and quercetin might help delay them.
research Genome-Wide Association Study and Transcriptome Differential Expression Analysis of the Feather Rate in Shouguang Chickens
Researchers found genes linked to feather growth speed in Shouguang chickens, highlighting two genes that might explain differences in feathering.
research SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin
Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.
research Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices
Different small areas within hair follicles send specific signals that control what type of cells stem cells become.
research Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment
The study demonstrated that Myc activation in mouse epidermis led to the depletion of the epidermal stem cell compartment by altering adhesive interactions with the local microenvironment. This was evidenced by the transcriptional analysis of over 10,000 genes, revealing that Myc activation induced genes related to RNA and protein synthesis, cell proliferation, and differentiation, while downregulating over 40% of genes associated with cell adhesion and cytoskeleton proteins. These changes impaired keratinocyte adhesion, motility, and wound healing, correlating with decreased expression of extracellular matrix proteins and integrins, and reduced formation of hemidesmosomes and actomyosin cytoskeleton assembly. Consequently, Myc activation prompted stem cell exit and differentiation into sebocytes and interfollicular epidermis at the expense of hair lineages, due to impaired keratinocyte migration necessary for hair differentiation.
research Dental Cell Type Atlas Reveals Stem and Differentiated Cell Types in Mouse and Human Teeth
The research identified various cell types in mouse and human teeth, which could help in developing dental regenerative treatments.
research An Update on Antiviral Treatment of COVID-19
As of December 2021, the most effective COVID-19 treatments were monoclonal antibodies and possibly early-administered convalescent plasma, while several drugs were found ineffective or were still under evaluation.
research The CLE40 and CRN/CLV2 Signaling Pathways Antagonistically Control Root Meristem Growth in Arabidopsis
CLE40 and CRN/CLV2 pathways have opposite effects on root growth in Arabidopsis.
research Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State
Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
research Effects of Minoxidil on Cultured Human Skin Fibroblasts
Minoxidil slows down skin cell growth and may help treat scars and skin conditions.
research A Screen for Key Genes and Pathways Involved in High-Quality Brush Hair in the Yangtze River Delta White Goat
Certain genes and pathways are crucial for high-quality brush hair in Yangtze River Delta White Goats.
research Identification of Key Genes Induced by Platelet-Rich Plasma in Human Dermal Papilla Cells Using Bioinformatics Methods
Platelet-rich plasma may help hair follicle cells grow by affecting certain genes and pathways.
research Exosomes as a Novel Pathway for Regulating Development and Diseases of the Skin
Exosomes are important for skin health and could help diagnose and treat skin diseases.
research The Investigation of the Possible Relationship Between Coxsackie Viruses and Pemphigus
No link found between Coxsackie viruses and pemphigus.
research Multiscale Spatial Mapping of Cell Populations Across Anatomical Sites in Healthy Human Skin and Basal Cell Carcinoma
The research created a detailed map of skin cells, showing that certain cells in basal cell carcinoma may come from hair follicles and could help the cancer grow.