Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism
July 2022
in “
Journal of Investigative Dermatology
”
hair follicle regeneration keratinocyte HIF-1α signaling glutamine metabolism Wound-Induced Hair Follicle Neogenesis WIHN skin-resident bacteria bacterial load hypoxia multi-omic analysis single-cell RNA sequencing murine skin human skin wounds broad-spectrum antibiotics glutamine production stem cell tolerance cutaneous antimicrobials skin bacteria low oxygen mouse skin antibiotics skin antimicrobials
Studysummary This study identified that bacterially-induced metabolic changes in keratinocytes enhance skin and hair follicle regeneration, suggesting that modifying skin microbiome interactions may improve wound healing.
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