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research A Canadian Algorithm on the Management of Telogen Effluvium.
This review consolidates the opinions of top Canadian dermatologists on managing telogen effluvium, highlighting the importance of proper diagnosis, identifying triggers, and patient education.
research Scalp Involvement in Primary Cutaneous Lymphomas—An Update on Clinical Presentation, Diagnostics, and Management
This review analyzed literature on primary cutaneous lymphomas involving the scalp, finding that scalp involvement in these cases often leads to non-scarring focal alopecia and may indicate more aggressive disease.
research The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review
This review examines sulforaphane's interactions with hormone-mediated health conditions, focusing on gender-specific health issues, but reports no new original research findings.
research THE EFFECT OF AUTOLOGOUS PLATELET RICH PLASMA (PRP) ON PATIENTS WITH ALOPECIA AREATA
In this study conducted at Al-Azhar University Hospital, 60% of patients with localized alopecia areata responded to treatment with autologous platelet-rich plasma, with 89% of responders showing substantial improvement, suggesting PRP as an effective treatment option for this condition.
research Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven by Multidisciplinary Collaborative Innovation
This review explores the mechanisms, current products, challenges, and innovative approaches related to cosmetics for hair loss prevention and growth promotion, emphasizing the need for multidisciplinary cooperation to enhance product development and market success.
research Evaluation of Olive Oil-Based Formulations Loaded with Baricitinib for Topical Treatment of Alopecia Areata
This study examined three olive oil formulations of baricitinib for topical delivery in treating alopecia areata, finding that Oil A showed the highest skin retention and maintained skin integrity without irritation, suggesting its potential for further investigation.
research Benefits of Testosterone Replacement and Methods of Substitution
This article discusses the various administration methods and considerations for testosterone replacement therapy, highlighting the importance of individualized therapeutic monitoring and potential adverse effects, but reports no new clinical results.
research Alopecia Areata: An Updated Review for 2023
Alopecia Areata affects 2% globally, with treatments like essential oils, garlic, and JAK inhibitors showing promise, but more research is needed.
research Androgens and ovarian function: translation from basic discovery research to clinical impact
This review summarizes research on androgens' roles in female reproductive function, noting their impact on IVF outcomes and the development of PCOS, and highlights the need for mechanism-based therapies.
research Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness
In this study, researchers conducted whole-genome resequencing of eight sheep breeds to identify additional genes associated with wool fineness, revealing 269 genes in fine wool and 319 in coarse wool breeds that are linked to significant traits and pathways.
research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions
This study provides the first direct evidence that spermidine can stimulate hair growth and modulate human epithelial stem cell biology in cultured human hair follicles.
research Cutaneous manifestations of COVID-19: a systematic review and analysis of individual patient-level data
This study found that livedoid and acro-ischemic skin manifestations were significantly associated with severe COVID-19, while chilblains-like eruptions appeared in less severe cases.
research Exploring the Efficacy and Potential Mechanisms of Topical Periplaneta americana (L.) Extract in Treating Androgenetic Alopecia in a Mouse Model: A Systems Pharmacology and Skin Microbiome Analysis
In this preclinical study, PA-011 derived from Periplaneta americana showed significant hair regrowth effects in androgenetic alopecia mouse models by inhibiting inflammation and oxidative stress, activating hair follicle stem cell proliferation, and normalizing skin microbiota, suggesting promise as an AGA treatment.
research Minoxidil to Treat Androgenetic Alopecia in Men and Women: What is It & How does It Work?
This article discusses the mechanisms of androgenetic alopecia and explores possible explanations for minoxidil's effect on hair growth but reports no new results.
research Reverse engineering liver buds through self-driven condensation and organization towards medical application
research Erythema multiforme sparing regressing herpes zoster lesion: “Reverse isotopic phenomenon?”
A patient's skin rash did not affect the area where a previous viral rash was healing, suggesting a rare immune response.
research Innovative modified hair follicle harvesting technique with reverse rake scalp elevator for lower occipital donor area in follicular unit extraction hair transplantation
This article describes a modified follicular unit extraction technique using a reverse rake scalp elevator, which may reduce follicular transection rates in hair transplantation from the lower occipital donor region.
research Screening of Anti-Hair Loss Plant Raw Materials Based on Reverse Network Pharmacology and Experimental Validation
This study explored the anti-hair loss potential of plant extracts like licorice, salvia miltiorrhiza, and others, finding they increased ALP and β-catenin expression and reduced TGF-β1 and IL-6 in human dermal papilla cells without cytotoxicity.
research Reverse Protein Engineering Of Firefly Luciferase
This study demonstrated that Reverse Protein Engineering can decrease the size of Firefly Luciferase from 550 to less than 80 amino acids, but further research is needed to ensure these smaller peptides retain bioluminescent activity.
research INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Simultaneous estimation of finasteride and tamsulosin hydrochloride by reverse phase HPLC in bulk and pharmaceutical dosage form
This investigation reports a new RP-HPLC method for accurately estimating Finasteride and Tamsulosin Hydrochloride in bulk and tablet forms, which may serve in routine pharmaceutical analysis.
research Analysis of Gene Expression in Isolated Single Hair Follicles: An Approach Using Semiquantitative Reverse-Transcriptase—Polymerase Chain Reaction
Researchers developed a new way to measure gene activity in single hair follicles and found that a specific gene's activity changes with different amounts and times of treatment.
research DETERMINATION OF FINASTERIDE AND RELATED COMPOUNDS BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. I. CHOOSING THE MOBILE PHASE COMPOSITION
This article discusses using high performance liquid chromatography to optimize mobile phase composition for separating synthesis products of Finasteride, without reporting new clinical results.
research REVERSED SEQUENTIAL THERAPY OF HIRSUTISM USING CYPROTERONE ACETATE
This study reports experience treating 140 women with hirsutism and other virilism signs using cyproterone acetate and ethinyl estradiol, focusing on those treated for over five months.
research The Telomerase Reverse Transcriptase (TERT) Gene Molecular Characterization in Sheep and the Association of Its Variation with Wool Traits
In this study, researchers found two non-synonymous SNPs in the TERT gene associated with mean wool staple strength in sheep, suggesting TERT as a potential candidate gene for improving wool traits.
research CS12192 Reverses Alopecia Areata by Selectively Targeting JAK3/JAK1/TBK1.
In this study, researchers evaluated CS12192, a selective JAK3 inhibitor, in an alopecia areata mouse model and found it reversed hair growth inhibition comparably to baricitinib, with better safety and similar immune-modulating mechanisms.
research Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles
This study found that combining lecithin reverse wormlike micelles with isopropyl myristate enhanced the skin permeability of a model hydrophilic drug, facilitated by interactions with sebum in hair follicles.
research Glibenclamide reverses cromakalim-induced anti-ischemic effect in conscious rabbits
research Ruxolitinib reverses alopecia areata via a triple mechanism: JAK-STAT inhibition, localized oxidative stress attenuation and selective apoptosis modulation
In this study using a mouse model with alopecia areata, the researchers found that ruxolitinib enhances hair regrowth by inhibiting the JAK-STAT signaling pathway, reducing inflammation and oxidative stress, and decreasing apoptosis, which supports its clinical effectiveness in treating this condition.
research Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism
This study suggests that intermediate-size hyaluronate fragments may enhance keratinocyte proliferation and improve skin thickness in atrophic conditions through a CD44-dependent mechanism.