Hypertrichosis and Hyperpigmentation in the Periocular Area Associated with Travoprost Treatment

    January 2015 in “ Annals of dermatology/Annals of Dermatology ”
    Hae-Eul Lee, Seul-Ki Lim, Myung Im, Chang Deok Kim, Young‐Joon Seo, Jeung‐Hoon Lee, Young Lee
    TLDR Using travoprost for glaucoma may cause extra hair growth and darker skin around the eyes, but these effects can reverse after stopping the drug.
    A 53-year-old Korean man with open-angle glaucoma developed hypertrichosis and hyperpigmentation in the periocular area after switching from latanoprost to travoprost. These adverse effects, including increased eyelash growth, appeared within 3 months of starting travoprost and improved 6 months after discontinuation. The study suggested that travoprost might have a stronger influence on hair growth and melanogenesis than latanoprost due to its higher potency in activating the prostaglandin F receptor. Physicians should be aware of these potential reversible side effects to manage patient treatment compliance effectively.
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