Enanthem in Patients With COVID-19 and Skin Rash

    July 2020 in “ JAMA Dermatology
    Juan ­Jimenez‐Cauhe, ­Daniel ­Ortega‐Quijano, Dario de Perosanz‐Lobo, Patrícia Burgos‐Blasco, Sergio Vañó‐Galván, Montse Fernández‐Guarino, Diego Fernández‐Nieto
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    Studysummary This study suggests that minoxidil may improve hypotrichosis in patients with ARWH due to LIPH variants, but a possible genetic factor could affect its efficacy within families.
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    This case series described the appearance of enanthem (oral cavity lesions) in 21 patients with COVID-19 and skin rash, confirmed by real-time reverse transcriptase–polymerase chain reaction. Enanthem was observed in 6 patients (29%), with lesions classified as macular, petechial, or macular with petechiae, all located in the palate. The study found that enanthem, particularly with a petechial pattern, strongly suggested a viral etiology rather than a drug reaction. The latency between COVID-19 symptoms and mucocutaneous lesions averaged 12.3 days. The study was limited by the small sample size and lack of a control group.
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