113 citations
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March 2018 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society” This review examines the adaptive value and mechanisms of seasonal coat colour moulting in birds and mammals, highlighting the challenge of camouflage mismatch and the necessity for evolutionary adaptation under climate change.
92 citations
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April 2009 in “Journal of Investigative Dermatology” The Celsr1 gene is crucial for normal hair patterning in mice.
1 citations
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January 1985 in “Protides of the biological fluids” This study found that injecting highly purified monocyto-angiotropin into hare skin induced new blood vessel formation and significantly accelerated hair growth at the injection site compared to control areas.
April 2018 in “Journal of Investigative Dermatology” This study identified the osteopontin-derived peptide, FOL-005, as a potential inhibitor of unwanted human hair growth by promoting catagen development without reducing stem cell numbers or showing toxicity.
January 2023 in “Indian Dermatology Online Journal” This study found that female pattern hair loss in Western India is often associated with metabolic syndrome, which correlates with earlier onset and increased severity.
169 citations
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June 1998 in “Journal of Investigative Dermatology” This study found no significant genetic association between the 5α-reductase enzyme genes and male pattern baldness, suggesting a polygenic etiology rather than simple inheritance.
19 citations
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April 2015 in “International Journal of Molecular Sciences” This study identified distinct gene expression patterns in wool follicle bulbs that may play important roles in wool follicle cycling and regeneration in sheep.
15 citations
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July 2015 in “Developmental Dynamics” This study highlights the role of Orai1 in ameloblast differentiation and maturation, showing that its down-regulation affects cell proliferation and enamel formation during tooth development.
6 citations
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December 2022 in “Biomedicines” This study found that the expression of the sonic hedgehog protein is involved in wound healing texture regeneration, inhibiting skin texture after embryonic day 14 and affecting keratinocyte migration and division.
In this study, 13 men with male pattern baldness were rated significantly more attractive and somewhat healthier when wearing a custom-made toupee, with higher attractiveness ratings coming from male judges than female judges.
7 citations
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May 2005 in “Experimental Dermatology” This study reports that two mouse models of scarring alopecia exhibit similar patterns of hair loss progression despite histological differences in inflammatory cell localization and MHC class I expression.
March 2025 in “International Journal of Trichology” This study found that, in female patients with pattern hair loss, injections of adipose-derived stem cells increased hair density and thickness, reduced perifollicular inflammation, and enhanced markers associated with hair cycle regeneration.
299 citations
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March 2001 in “Journal of Investigative Dermatology” This study found that specific genetic markers near the androgen receptor gene are significantly more common in men with male pattern baldness, suggesting a genetic component in its development.
81 citations
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September 2009 in “Birth defects research” This review discusses the mechanisms behind hair patterning during mouse embryonic development and reports no new experimental findings.
55 citations
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November 2010 in “Development” This study observed that in frizzled 6 null mice, initially uncorrelated hair follicle orientations develop into highly ordered patterns over time, suggesting possible mechanisms for biological structure patterning.
14 citations
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January 2008 in “Dermatology Online Journal” This review discusses the use of anti-hormonal therapies for female androgenetic alopecia and notes that while some treatments show promise, larger controlled studies are needed to define their roles and effectiveness.
5 citations
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February 2025 in “Journal of Clinical Medicine” This study introduced a non-invasive, three-step diagnostic algorithm for alopecia that combines clinical and trichoscopic features to accurately identify alopecia subtypes, potentially reducing reliance on invasive histopathology.
3 citations
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January 2023 in “Agronomy” This research reported that KDML105 bran extract demonstrated antioxidant activities, reduced nitric oxide production, and influenced gene expression related to the hair cycle in cultured dermal papilla cells, suggesting potential as an anti-hair loss agent by supporting the anagen phase and angiogenesis.
2 citations
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June 2022 in “International Journal of Molecular Sciences” This study found variable outcomes in hair loss treatment with autologous cell-based therapy using DSC cells, with certain gene markers showing inconsistent correlations with treatment efficacy.
1 citations
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August 2024 in “Polymers” This study observed that dissolving microneedles made from PVP-K90 and HPMC E50, incorporating Oryza sativa L. extract complex, showed enhanced transfollicular skin penetration and maintained safety for keratinocytes, with the P25H5 formulation demonstrating faster dissolution and greater effectiveness.
July 2026 in “Journal of Cutaneous and Aesthetic Surgery” This review suggests that female and male hair loss patterns differ due to hormonal influences, metabolic factors, and genetic loci, with female pattern hair loss potentially occurring without androgen influence, highlighting the need for distinct clinical management approaches.
February 2026 in “International Journal of Molecular Sciences” This study found that PDLLA filler treatment may help combat age-related hair thinning by reducing oxidative stress and enhancing hair follicle function in both cell and animal models.
June 2025 in “Microorganisms” In this study, researchers observed significant differences in hair follicle microbiome diversity and microbial composition between hair loss and healthy groups, uncovering specific patterns and functional changes associated with female pattern hair loss, which may aid future targeted approaches for androgenetic alopecia.
May 2025 in “Egyptian Journal of Dermatology and Venerology” This study found that specific SNPs in the CYP19A1 gene were associated with Female Pattern Hair Loss in Egyptian women, with altered CYP19A1 gene expression and higher frequencies of related genotypes observed in patients compared to controls.
May 2023 in “Scientific Reports” This study found that Lepidium sativum seed extract showed potential in treating alopecia in rats by reducing 5(alpha)-dihydrotestosterone levels and improving hair length compared to minoxidil.
January 2023 in “Journal of surgery and research” This article discusses various treatments for androgenetic alopecia and reports no new clinical results, noting the condition's aesthetic and psychological impact.
October 2021 in “Cosmoderma” This review summarizes existing knowledge on diffuse and patterned alopecia, emphasizing recent advancements in treatment beyond FDA-approved options, but it reports no new clinical findings.
July 2021 in “Journal of dermatology research and therapy” In this study, researchers observed an increased incidence of pattern hair loss and telogen effluvium among COVID-19 patients, potentially linked to psychological stress, systemic inflammation, and oxidative stress, with reduced anagenic expression of proteoglycans suggested as a mediating mechanism.
January 2008 in “Dermatology Online Journal” This review explores potential treatments for female androgenetic alopecia, noting that anti-hormonal therapies may be beneficial for some women, but emphasizes the need for further research and effective solutions.
February 2026 in “Advanced Science” This study found that the combination of TTNPB and CHIR99021 enhanced the derivation of highly advanced neural stem cells from human pluripotent stem cells, with improved chromatin accessibility and neuroectodermal gene expression, and these cells successfully engrafted in rat hippocampi to ameliorate depression-like symptoms.