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Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.

Premature hair graying in young men is linked to family history, obesity, and smoking.

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Using topical minoxidil for baldness can cause heart problems, especially in those with heart disease.

Finasteride 5 mg/day effectively treats hair loss in postmenopausal women without hyper-androgenism.

Alopecia areata seriously lowers quality of life, especially affecting self-image, mental health, and social life.

New research on prostamide F2α has led to treatments for glaucoma and eyelash growth and may have more medical uses.

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.

Hair follicle regeneration possible, more research needed.

Hair growth is influenced by various body and external factors, and neighboring hairs communicate to synchronize regeneration.

Basal cell carcinomas have much higher levels of Vitamin D3 receptors compared to healthy skin.

Melatonin may help treat PCOS symptoms in rats.

Over 60% of Korean military personnel had skin diseases, commonly acne and athlete's foot, linked to service length and stress.

Prolactin may be important for skin growth and immune function.

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

Some alternative treatments for hair loss might work, but more research is needed.

JAK inhibitors show promise for treating skin and hair disorders but need more research on long-term safety and effectiveness.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

Certain diets can affect skin conditions, but more research is needed to understand these relationships fully.

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

The document suggests using standardized methods to track and measure hair loss in alopecia areata, including patient self-assessment and a 50% improvement in specific scores as a treatment goal.

Epidermal keratinocytes start wound healing and inflammation after schistosome infection.

Skin diseases are very common in poor areas, and there's a need for affordable ways to manage and improve skin health.

Many skin patients have mental health issues, but few dermatologists are well-versed in treating these conditions.

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

Skin diseases significantly lower the quality of life for patients in southern Brazil, especially for younger, single, and lower-income individuals.