Practical Whole-Tooth Restoration Utilizing Autologous Bioengineered Tooth Germ Transplantation in a Postnatal Canine Model

    March 2017 in “ Scientific Reports ”
    Mitsuaki Ono, Masamitsu Oshima, Miho Ogawa, Wataru Sonoyama, Emilio Satoshi Hara, Yasutaka Oida, Shigehiko Shinkawa, Ryu Nakajima, Atsushi Mine, Satoru Hayano, Satoshi Fukumoto, Shohei Kasugai, Akira Yamaguchi, Takashi Tsuji, Takuo Kuboki
    TLDR Bioengineered tooth germ can restore whole teeth in dogs.
    This study demonstrated the potential for whole-tooth restoration by transplanting bioengineered tooth germ in a postnatal canine model. The bioengineered tooth, created from permanent tooth germ cells, successfully erupted into the jawbone and functioned similarly to a natural tooth. This research marked a significant step forward in whole-organ replacement therapy, suggesting practical applications for future clinical regenerative medicine.
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