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    Glossary Regulatory T Cells

    specialized immune cells that prevent autoimmune responses

    Regulatory T Cells, often abbreviated as Tregs, are a specialized subset of T cells in the immune system that help maintain immune tolerance and prevent autoimmune diseases. They function by suppressing the activity of other immune cells, thereby preventing excessive or misdirected immune responses that could damage the body's own tissues.

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    1. Decreased CD19+CD24hiCD38hi Regulatory B Cells in Alopecia Areata Journal of Investigative Dermatology · 2024 · 5 citations
    2. 148 Decreased IL-10 producing regulatory B cells in patients with alopecia areata 2023
    3. Regulatory T cells in autoimmune skin diseases Experimental Dermatology · 2018 · 24 citations
    4. Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration Frontiers in Immunology · 2018 · 188 citations
    5. Regulatory T cells in skin Immunology · 2017 · 110 citations
    6. Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata Journal of Investigative Dermatology · 2002 · 77 citations
    7. The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris Frontiers in Immunology · 2022 · 49 citations
    8. Regulatory T cells in inflammatory skin disease: from mice to humans International immunology · 2019 · 43 citations
    9. Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity 2019 · 39 citations
    10. Regulatory T cells in dominant immunologic tolerance Journal of Allergy and Clinical Immunology · 2023 · 26 citations
    11. Regulatory T cells in skin regeneration and wound healing 2023 · 3 citations
    12. Regulatory T Cells in Autoimmune Diseases and their Potential Journal of Investigative Dermatology Symposium Proceedings · 2005 · 3 citations
    13. Regulatory T cell dysfunction and immunotherapeutic breakthroughs in type 1 diabetes Frontiers in Endocrinology · 2026 · 2 citations
    14. HuR ablation destabilizes Foxp3 mRNA and impairs regulatory T cell function, contributing to an autoimmune phenotype Frontiers in Immunology · 2025 · 1 citations
    15. Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers International Journal of Molecular Sciences · 2023 · 1 citations
    16. Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration Cell Reports · 2025
    17. The potential of regulatory T cell-based therapies for alopecia areata Frontiers in Immunology · 2023
    18. Role of regulatory T cells in psoriasis pathogenesis and treatment British Journal of Dermatology · 2020 · 273 citations
    19. Regulatory T Cells: the Many Faces of Foxp3 Journal of Clinical Immunology · 2019 · 125 citations
    20. T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities 2018 · 66 citations
    21. Imbalance of T‐helper 17 and regulatory T cells in patients with alopecia areata The Journal of Dermatology · 2015 · 62 citations
    22. Regulatory T cells are required for normal and activin‐promoted wound repair in mice European Journal of Immunology · 2018 · 29 citations
    23. CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment Immunity · 2024 · 28 citations
    24. Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche Science Immunology · 2024 · 21 citations
    25. Regulatory T‐cells in alopecia areata Journal of cutaneous pathology · 2019 · 21 citations
    26. CD80CD86 deficiency disrupts regulatory CD4+FoxP3+T cell homoeostasis and induces autoimmune-like alopecia Experimental dermatology · 2017 · 6 citations
    27. Regulatory T cells: master orchestrators of immune tolerance and tissue homeostasis Frontiers in Science · 2026 · 2 citations
    28. Skin stem cells orchestrate <i>de novo</i> generation of extrathymic regulatory T cells to establish a temporary protective niche during wound healing bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 2 citations
    29. The Role of T‐Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis The Journal of Dermatology · 2025 · 1 citations
    30. Beyond immune suppression: regenerative programs in regulatory T cells Cell Insight · 2026