Comparison of Comedolytic Effect of Benzoyl Peroxide and Adapalene in Rhino Mice

    Keisuke Tabara, Rie Tamura, Kazuaki Okamoto, Takamichi Kitano, Yusuke Kumagai, Shoji Kanayama, Tomo Sasaki, Takayasu Moroki, Sachi Mori, Fumiaki Ikeda, Takuya Matsumoto
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    TLDR Benzoyl peroxide and adapalene gels work differently to reduce acne in mice.
    The study compared the effects of 2.5% benzoyl peroxide (BPO) gel and 0.1% adapalene gel on the comedones of rhino mice, a model known for spontaneous comedone formation. The mice were treated with either BPO for up to 9 weeks or adapalene for up to 3 weeks. Results indicated that BPO gel reduced comedone size after 7 and 9 weeks without affecting their number and slightly thickened the epidermis. In contrast, adapalene gel decreased both the size and number of comedones and significantly thickened the epidermis after 3 weeks, also altering the mRNA expression of differentiation factors and cell adhesion molecules. The study concluded that BPO and adapalene gels have distinct mechanisms of action in their comedolytic effects.
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