Comparison of Comedolytic Effect of Benzoyl Peroxide and Adapalene in Rhino Mice

    April 2017 in “ Journal of Dermatological Science ”
    Keisuke Tabara, Rie Tamura, Kazuaki Okamoto, Takamichi Kitano, Yusuke Kumagai, Shoji Kanayama, Tomo Sasaki, Takayasu Moroki, Sachi Mori, Fumiaki Ikeda, Takuya Matsumoto
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    TLDR Benzoyl peroxide and adapalene gels work differently to reduce acne in mice.
    The study compared the effects of 2.5% benzoyl peroxide (BPO) gel and 0.1% adapalene gel on the comedones of rhino mice, a model known for spontaneous comedone formation. The mice were treated with either BPO for up to 9 weeks or adapalene for up to 3 weeks. Results indicated that BPO gel reduced comedone size after 7 and 9 weeks without affecting their number and slightly thickened the epidermis. In contrast, adapalene gel decreased both the size and number of comedones and significantly thickened the epidermis after 3 weeks, also altering the mRNA expression of differentiation factors and cell adhesion molecules. The study concluded that BPO and adapalene gels have distinct mechanisms of action in their comedolytic effects.
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