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ANA-negative lupus nephritis can be diagnosed and treated effectively with a comprehensive approach.

Taking 1 mg finasteride for a year reduces dihydrotestosterone levels in men with early hair loss, but doesn't change their metabolic state.

Both metformin and pioglitazone improve PCOS symptoms, but pioglitazone is a good alternative for those who can't take metformin.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Fructus Malvae may help with diabetes, tumors, and hair loss due to its various active compounds.

Antioxidant-rich diets may reduce hair loss risk, while pro-inflammatory diets may increase it, especially in women.

The ABCA4 gene protects hair follicle stem cells from toxic vitamin A byproducts.

The document concludes that managing Dunnigan-Type Familial Partial Lipodystrophy involves treating associated health issues and using medications like metformin and leptin replacement.

Low PON1 levels may indicate and predict the severity of hair loss.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Licorice has many health benefits but should be used carefully due to possible side effects.

Oral isotretinoin may slightly improve acne but increases the risk of side effects like dry lips and skin; more research is needed to understand its full risks and benefits.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

PPAR-γ helps control skin oil glands and inflammation, and its disruption can cause hair loss diseases.

High BMI worsens hair growth in women with PCOS.

High-dose vitamin A and E with zinc improved blood sugar control and insulin function in diabetics, but may cause hair loss.

Synthetic antioxidants are effective, cheap, and stable, with some like zinc and cholecalciferol reducing child and cancer deaths, but the safety of additives like BHA, BHT, TBHQ, and PEG needs more research.

More high-quality research is needed to recommend flavonoids and saponins for clinical use.

Anti-androgens can help manage some PCOS symptoms better than metformin but are not more effective than placebos or birth control pills for other symptoms.

Isotretinoin therapy for acne can cause many reversible side effects, mainly mild skin conditions, and patient understanding of these effects can improve treatment adherence.

Polycystic ovary syndrome, a disorder causing menstrual issues and infertility, can be treated with lifestyle changes, medication, herbal remedies, surgery, and assisted reproductive techniques like artificial insemination and IVF.

Mesenchymal stem cells could help treat aging-related diseases better than current methods.

Nanocarriers can improve antioxidant delivery to the skin but face safety and production challenges.

Mitochondrial dysfunction links metabolic syndrome and inflammatory skin diseases, suggesting targeted therapies and lifestyle changes.

Finasteride in male rats causes liver and metabolic issues in their offspring.

Long-term high testosterone levels can improve bone density and reduce body fat but may increase the risk of prostate cancer and high blood pressure.

DHEA supplementation may improve quality of life, neuropsychological functions, and sexual satisfaction in individuals with adrenal insufficiency, but more research is needed to confirm its safety and effectiveness.

People with early-onset androgenetic alopecia may have a higher risk of heart disease due to abnormal blood lipid levels.

Finasteride lowers good cholesterol, raises bad fats, and may increase heart disease risk.

Women with PCOS and higher androgen levels are more likely to have fatty liver disease.