Effect of Body Mass Index on Phenotypic Features of Polycystic Ovary Syndrome in Singapore Women: A Prospective Cross-Sectional Study

The study examined the impact of BMI on the phenotypic features of PCOS in Singaporean women, involving 200 participants. It found that higher BMI was associated with more severe PCOS symptoms, such as increased hirsutism, menstrual irregularities, and metabolic disturbances. Specifically, high BMI exacerbated hair growth (mFG scores) and free androgen index (FAI) in PCOS women, while not independently affecting oligomenorrhea, antral follicle count, ovarian volume, or serum androgens. The study concluded that weight management could be crucial in treating and managing PCOS, suggesting lifestyle interventions as a first-line treatment to manage symptoms and metabolic issues.