Among participants in a 26-week trial, this study by REVIAN Inc. reported that their REVIAN RED dual wavelength LED light treatment for androgenetic alopecia was both safe and effective at the 16-week mark.
February 2023 in “Cosmoderma” This study found that combining red light therapy with oral beta-carotene significantly improved photoaging treatment outcomes compared to red light therapy alone, with Group A showing a 56.12% reduction in photoaging scores over 12 weeks versus 44.78% in Group B.
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that low-level pulsed wave red light stimulated collagen and ATP production in human fibroblasts with significantly shorter treatment time than continuous wave light, suggesting enhanced consumer compliance for skin treatments.
19 citations
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February 2018 in “Lasers in Medical Science” This study found that 655-nm red light with LED enhanced hair shaft elongation and reduced catagen transition in human hair follicles in vitro by activating the Wnt/ß-catenin signaling pathway.
6 citations
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September 2018 in “Journal of Dermatological Treatment” This review examines the FDA's 510(k) approval process for low-level laser therapy devices used in treating androgenetic alopecia and reports no new clinical findings.
September 2025 in “International Journal of Innovative Technologies in Social Science” This article reviews the versatile applications of red and infrared light therapy, reporting that these treatments can enhance skin health by modulating cellular processes such as RNA and protein synthesis, oxygen consumption, and reducing oxidative stress and inflammation.
March 2025 in “Egyptian Journal of Animal Health” This study observed that supplementing buffalo calves with a mineral mixture alone or combined with Nigella sativa seeds improved skin conditions and hematobiochemical parameters in calves suffering from parakeratosis, which is primarily due to zinc deficiency.
January 2023 in “Dermatologic Therapy” This study evaluated a novel hand-held low-level light therapy device for treating mild-to-moderate acne, finding it significantly reduced inflammatory lesions and moderate acne severity without severe adverse reactions, while also reducing Cutibacterium acnes viability in vitro.
January 2016 in “프로그램북(구 초록집)” In this study, LED irradiation was found to promote hORSC proliferation and stimulate the Wnt5a/β-catenin and ERK signaling pathways, suggesting a potential mechanism for hair growth.
January 2026 in “Forum Dermatologicum” This review concluded that LED-based photobiomodulation is generally safe and effective for certain dermatologic conditions, though consumer devices often show less efficacy compared to professional systems.
January 2026 in “American Journal of Medical and Clinical Research & Reviews” The study discusses using red light therapy for hair regrowth, noting red light alone may aid non-inflammatory hair loss, while infrared-red light combination is necessary for conditions like alopecia areata.
2 citations
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August 2021 in “Photodiagnosis and Photodynamic Therapy” In this study, 5-aminolevulinic acid photodynamic therapy did not improve hair growth in patients with androgenetic alopecia but was safe and slightly reduced scalp sebum secretion.
May 2026 in “Frontiers in Medicine” This study concluded that combining the Shumin treatment instrument with oral doxycycline provides better clinical outcomes for rosacea than combining red light therapy with doxycycline, while both regimens improved quality-of-life scores and reduced Demodex counts.
4 citations
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September 2023 in “Journal of Dermatological Treatment” In this study, the use of wellness apparel emitting red and NIR light was associated with improved disease severity in patients with mild elbow psoriasis, PMLE, and limited AA, though the small sample size and continued use of other treatments were noted as limitations.
July 2025 in “Current Treatment Options in Oncology” This opinion piece discusses strategies for managing cancer-related alopecia, emphasizing personalized approaches including scalp cooling and topical minoxidil, but it reports no new clinical results.
May 2023 in “Brazilian Journal of Animal and Environmental Research” In this study, photobiomodulation therapy using EccoVet® equipment was applied to a canine patient with alopecia, leading to noticeable hair regrowth after just one session and complete improvement after five, highlighting its potential as a fast, non-invasive treatment for canine alopecia.
December 2018 in “Zenodo (CERN European Organization for Nuclear Research)” This review of low-level laser therapy for patterned hair loss found that red-spectrum light may be effective for hair growth, but larger case-controlled studies are needed to further support this conclusion.
December 2024 in “Dermatological Reviews” This review highlights significant advances in understanding and treating Alopecia Areata, emphasizing the effectiveness of JAK inhibitors like baricitinib, ritlecitinib, and deuruxolitinib for systemic treatment, while also noting ongoing research into new therapeutic approaches such as stem cell therapy and energy-assisted drug delivery.
1 citations
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March 2024 in “International Journal of Dermatology” This case report describes a therapy-resistant folliculitis decalvans patient who showed nearly complete response with increased hair density after treatment with CO2 laser-assisted photodynamic therapy.
January 2018 in “Archives of dermatology and skin care” This systematic review found widespread support in existing literature for the effectiveness of low level laser therapy in promoting hair growth, but emphasized the need for larger case-controlled studies to confirm these results.
6 citations
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January 2021 in “Annals of Dermatology” This study found that 650-nm red light treatment promoted hair follicle proliferation and delayed the transition from anagen to catagen in ex vivo hair follicles from androgenetic alopecia patients, with RNA-seq analysis suggesting involvement of biological processes like metabolism and leukocyte migration.
2 citations
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May 2023 in “Photobiomodulation, photomedicine, and laser surgery” This editorial reviews how photobiomodulation therapy might effectively treat both hyperpigmentation and depigmentation skin disorders, but reports no new clinical results.
2 citations
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November 2025 in “Healthcare” This study found that among young patients with acne vulgaris, combining a 675 nm red-light laser with isotretinoin led to more rapid and pronounced improvement in lesion severity compared to laser treatment alone, without adverse events.
October 2025 in “Dermatologica Sinica” This study's network meta-analysis reported that botulinum injection combined with red laser and topical minoxidil is most effective for increasing hair density in androgenetic alopecia when using low-level laser therapy.
In this study involving two volunteers with Androgenetic Alopecia, phototherapy using red and blue wavelengths promoted benefits, as observed through photographic and trichoscopy comparison after 12 weekly sessions.
November 2025 in “Revista Multidisciplinar do Nordeste Mineiro” This study's review of existing literature suggests potential benefits of red LED photobiomodulation for treating telogen effluvium, but highlights a lack of standardized parameters and calls for further controlled trials.
1 citations
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November 2021 in “IntechOpen eBooks” This review covers red light Transcranial LED therapy for hippocampal memory impairment in aging and Alzheimer's but reports no clinical results, highlighting a need for further research into its mechanisms and effects.
9 citations
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August 2017 in “Photochemistry and Photobiology” This study found that isolated red light may serve as an alternative for photo-immunotherapy without additional photosensitizers, as it did not reduce keratinocyte differentiation markers or increase photo-oxidative damage, unlike treatment with IL-4 or UVA1/blue light.
18 citations
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January 2023 in “Nano Research” This study found that red OLED irradiation can significantly promote hair regrowth in mice, increasing hair length by 1.5 times and hair regrowth area by over 3 times after 20 days of treatment.
January 2024 in “Annals of Agricultural and Environmental Medicine” This study observed that LED therapy improved hair regrowth and reduced hair loss in patients with post-COVID telogen effluvium, with or without androgenetic alopecia, compared to those who did not receive LED treatment.