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This study concluded that 16β-methyl-17α-benzoyloxypregnen-4-en-3,20-dione may be a promising treatment for androgen-dependent diseases and epilepsy due to its antioxidant effects and impact on GABAergic and serotonergic metabolism in rats.

New oral treatment, finasteride, effectively and safely treats common hair loss.

This narrative review highlights the potential of autologous adipose mesenchymal stem cell-derived exosomes (AMSCs-Exos) in anti-skin aging, noting their superior biocompatibility and manufacturing advantages while stressing the need for standardized production protocols to overcome existing application challenges.

This review discusses how androgens, commonly known for male reproductive roles, also influence the physiology and pathology of the human endometrium, though their exact roles in this tissue remain controversial and not fully understood.

In this review, researchers explored the multifaceted role of NF-κB signaling in various biological processes and diseases, including its interactions with other pathways, and discussed possible therapeutic approaches targeting this pathway for treating conditions like cancer, autoimmune disorders, and COVID-19.

This study found that stimulating toll-like receptor 5 via mucosal delivery of a flagellin-containing fusion protein effectively extended lifespan and enhanced healthspan in mice, including improved bone density and cognitive capacity.

This study evaluated a new computer-aided detection system for identifying Breast Arterial Calcification in mammograms, achieving 70% accuracy, but highlighted the need for a larger dataset to explore its relationship with cardiovascular diseases.

This study found that testosterone concentrations in hair samples were moderately stable over three months, with cosmetic treatments like coloring increasing testosterone levels, while natural hair color in untreated hair did not affect testosterone measurements.

This study found that dihydrotestosterone treatment in female rats altered anterior pituitary gland gene expression, with significant repression of prolactin and inhibition of GnRH receptor gene expression, suggesting specific hormone production changes.

This study found that finasteride treatment of male rats led to changes in their male offspring's testicular gene expression, potentially affecting sperm function in response to odorant-like signals.

This study suggests that finasteride is a safe and effective alternative therapy for women with hidradenitis suppurativa who have contraindications or intolerance to spironolactone.

This review examines the use of natural remedies, including various herbs, for treating polycystic ovary syndrome, but reports no new clinical results.

In this study, the ethanol extract of Zapoteca portoricensis stem significantly reduced markers of testosterone-induced benign prostate hyperplasia in male albino rats without harming liver and kidney function.

This review examines the effects of antiandrogens on female reproductive systems, particularly regarding environmental endocrine disruptors, and presents no new research findings.

This study found that young women with PCOS exhibited altered white matter microstructure and reduced cognitive performance compared to matched controls.

This study observed that human dental pulp stem cells can differentiate into adipocytes and osteocytes, but their potential for neural differentiation remains uncertain due to similar responses seen in undifferentiated cells.

This article discusses the potential of acupuncture as a complementary or alternative therapy for PCOS, highlighting experimental evidence of its positive effects on reproductive and metabolic function, but reports no new clinical results.

Some human genetic markers work for genetic studies in pig-tailed and stump-tailed macaques, which can help in their conservation.

Finasteride may decrease semen quality but not harm sperm production, and stopping the drug can improve semen quality; hyperprolactinemia can cause infertility but is treatable with medication.

Finasteride improves hair growth and satisfaction in men with male pattern baldness but may cause sexual side effects.

The patient's hair loss was likely not caused by beta blockers but possibly by stress or other factors.

In this study, researchers reported no significant association between ABO or Rh blood groups and the incidence of hidradenitis suppurativa among patients compared to healthy controls.

This review highlights the promising clinical outcomes of sacituzumab tirumotecan (sac-TMT), an antibody-drug conjugate for breast cancer that targets TROP2, demonstrating improved response rates and progression-free survival, with manageable safety concerns including primarily mild-to-moderate nausea and alopecia.

This study discusses the complex roles and effects of brain-synthesized sex neurosteroids, highlighting sex differences in their concentrations and their varied impacts on synaptic plasticity, cognitive behavior, and aging-related cognitive decline.

This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.

This study developed a non-invasive, partially automated protocol for extracting high-quality DNA from hair follicles of marmosets, significantly reducing chimerism rates compared to blood, and proving reliable for whole genome sequencing in low-input DNA scenarios.

This study conducted in Batam City found a 10.79% prevalence of alopecia among 417 captured bats across seven species, with higher rates in fragmented urban forests associated with anthropogenic pressures, highlighting the influence of habitat conditions on bat health.

This study found that keratin hydrolyzed, egg yolk lecithin, and fish collagen peptide promoted β-catenin nuclear translocation and increased gene expression related to hair regeneration in canine and cat skin cell lines, suggesting these nutrients may help improve hair regeneration in pets.

This review discusses the use of experimental animal models to better understand the poorly understood mechanisms behind polycystic ovarian syndrome and reports no new clinical results.

This review found that hormones significantly impact women's health and athletic performance, influencing the menstrual cycle, menopause, and exercise responses, while therapies like contraception and hormone replacement require personalized approaches to balance benefits and risks.