Finasteride and Male Fertility

January 2011 in “ Journal of Human Reproductive Sciences ”

Dilip Gude

Studysummary Finasteride may decrease semen quality but not harm sperm production, and stopping the drug can improve semen quality; hyperprolactinemia can cause infertility but is treatable with medication.

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research Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage

36 citations , February 2011 in “Fertility and Sterility”

This case report suggests that discontinuing low-dose finasteride in a 48-year-old man led to a significant reduction in sperm DNA fragmentation index, indicating a possible link between finasteride and sperm DNA damage.

research Finasteride-Associated Male Infertility

38 citations , December 2010 in “Fertility and Sterility”

In this case report, a male patient's semen parameters improved after discontinuing a 1-mg dose of finasteride, suggesting that stopping the medication may benefit infertile men with previous sperm production issues.

research Effect of 1-Mg Dose of Finasteride on Spermatogenesis and Pregnancy

11 citations , March 2010 in “International Journal of Andrology”

This article reviews multiple entries on the Androlog blog regarding finasteride use, concluding that a 1-mg dose does not adversely affect spermatogenesis or pose a risk during conception or pregnancy.

research Propecia-Induced Spermatogenic Failure: A Report of Two Cases

49 citations , December 2007 in “Fertility and Sterility”

This case report describes two infertile patients who experienced significant improvements in sperm concentrations six months after stopping finasteride.

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations , February 2007 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.

research Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men

104 citations , October 1999 in “The Journal of Urology”

This study concluded that daily treatment with 1 mg finasteride did not affect spermatogenesis or semen production in young men and had small, reversible effects on prostate volume and serum PSA.