January 2010 in “Springer eBooks” This review discusses the psychological and social challenges of hirsutism in women and suggests that eflornithine cream may offer a small quality of life improvement for affected individuals, though with limited evidence.
14 citations
,
September 2018 in “JAMA Facial Plastic Surgery” This study found that hair transplant surgery significantly improves health utility scores compared to untreated androgenetic alopecia in both men and women, as perceived by laypeople.
March 2026 in “The Journal of Dermatology” This study found that ritlecitinib 50 mg is cost-effective compared to no treatment for patients in Japan with alopecia areata and significant scalp hair loss, demonstrating an incremental cost-effectiveness ratio below the country's cost-effectiveness threshold.
150 citations
,
March 1995 in “Annals of Oncology” This study reported that palliative chemotherapy prolonged overall and quality-adjusted survival in patients with advanced gastric cancer, with improved quality of life compared to best supportive care, but increased costs.
24 citations
,
August 2005 in “Health and Quality of Life Outcomes” This study observed that women aged 63 with androgenetic alopecia had higher insulin resistance and more role limitations due to physical health compared to those with normal hair.
17 citations
,
January 2024 in “Journal of Korean Medical Science” This study highlights the urgent need for health policies in Korea that focus on diseases with rising burdens and groups experiencing high health burdens, as a step toward improving population health and achieving health equity.
July 2025 in “International Journal of Pharmaceutical Sciences Review and Research” This case report documented a 20-year-old male with alopecia areata who experienced slight hair regrowth following treatment with cyclosporine and methylprednisolone, highlighting the importance of individualized treatment plans and consideration of medication side effects.
February 2026 in “Clinical Cosmetic and Investigational Dermatology” This study found that while the global incidence of alopecia areata in individuals aged 0–19 declined from 1990-2021, the total number of cases rose, with higher burdens among females, adolescents, and low-SDI populations, particularly in Central Sub-Saharan Africa; disparities suggest a need for targeted interventions.
34 citations
,
November 2020 in “Biomedical Physics & Engineering Express” This study observed that using DNA nanostructures to deliver chemotherapy drugs could potentially reduce costs compared to traditional methods, with financial barriers being less significant than technical, regulatory, and ethical challenges.
1 citations
,
April 2016 in “Plastic and Reconstructive Surgery – Global Open” This study concluded that oncoplastic breast surgery is a more cost-effective treatment than standard lumpectomy for large-breasted patients, despite higher initial costs.
April 2011 in “The Journal of Urology” This study concluded that finasteride is most cost-effective for prostate cancer chemoprevention when started at age 65 and continued until age 80.
70 citations
,
May 2014 in “JAMA Dermatology” This study found that systematic review and protocol topics in the Cochrane Database for skin conditions are partly aligned with disease burden metrics, with some conditions overrepresented and others underrepresented compared to their disability-adjusted life years.
11 citations
,
July 2022 in “Frontiers in immunology” This study reports that the global age-standardized incidence and disability-adjusted life-year rates of alopecia areata decreased from 1990 to 2019, with the highest increases in incidence seen in some low SDI regions and countries like Kuwait and South Sudan.
2 citations
,
September 2022 in “Frontiers in Nutrition” This study found no significant difference in the persistence of new symptoms or quality of life improvements with 200,000 IU of vitamin D3 compared to placebo in patients post-COVID-19 hospitalization.
January 2025 in “Therapeutic Advances in Medical Oncology” This study found that many young women with breast cancer experience a poor quality of life over time, especially regarding sexual health, future perspective, and hair loss.
April 2023 in “Journal of Investigative Dermatology” Alopecia areata significantly affects emotional well-being and quality of life, especially in younger adults.
September 2025 in “Journal of the American Academy of Dermatology” Eyebrow and eyelash hair loss in alopecia areata worsens quality of life.
16 citations
,
January 2017 in “Asian journal of andrology/Asian Journal of Andrology” This study found that older age at puberty may be associated with lower semen quality and altered reproductive hormone levels in young men, though only some results were statistically significant.
48 citations
,
April 2015 in “PLOS ONE” In this study, hirsutism was found to have the most significant negative impact on health-related quality of life among Iranian women with polycystic ovary syndrome.
3 citations
,
November 2022 in “International journal of environmental research and public health/International journal of environmental research and public health” This study observed that ethnic Indian women with PCOS often experience early symptom onset, delays in diagnosis, and report poor quality of life, highlighting the need for culturally tailored healthcare approaches.
10 citations
,
July 2021 in “International Journal of Rheumatic Diseases” This review summarizes evidence indicating that body image issues in patients with systemic lupus erythematosus should be addressed with the same importance as physical symptoms like pain and disability.
71 citations
,
July 2015 in “The Journal of Clinical Endocrinology and Metabolism” This study found that women with PCOS have elevated serum androgen levels throughout adulthood, with these levels decreasing and variations increasing as they approach menopause.
59 citations
,
August 2018 in “The oncologist” This study found that permanent chemotherapy-induced alopecia was relatively common three years after treatment among breast cancer patients receiving adjuvant chemotherapy, particularly those on taxane-based regimens.
In this case report, a 35-year-old woman was diagnosed with Sheehan's syndrome years after severe postpartum hemorrhage, leading to multiple hormonal deficiencies, highlighting delayed diagnosis's impact on treatment and quality of life.
In this study, researchers found that the health state utility of moderate facial angiofibroma in Tuberous Sclerosis Complex patients is significantly lower compared to almost-clear facial angiofibroma, indicating that treatment for the condition can substantially improve quality of life.
October 2025 in “Animals” This study reported that horses with pituitary pars intermedia dysfunction had improved coat condition, advanced shedding, and better quality of life when treated with blue light masks.
May 2025 in “Clinical and Translational Allergy” This qualitative review reports a high socioeconomic impact of atopic dermatitis and alopecia areata, emphasizing significant quality of life reductions and increased costs, but highlights a lack of comprehensive data from many regions worldwide, underscoring the need for global studies with standardized methodologies.
12 citations
,
November 2020 in “Transplant international” In this study, researchers observed that hand and forearm transplantation at Innsbruck Medical University showed variable long-term outcomes, with the severity of rejection episodes impacting patients' well-being and quality of life but not directly correlating with hand function.
15 citations
,
March 2024 in “Journal of Clinical Medicine” In this four-year study, pediatric patients with inoperable plexiform neurofibromas and type 1 neurofibromatosis treated with selumetinib frequently experienced dermatologic side effects, which required tailored management strategies and sometimes led to treatment suspension, potentially affecting tumor regrowth.
19 citations
,
September 2017 in “The Journal of urology/The journal of urology” In this study, the researchers found that worse sleep scores were associated with progression of lower urinary tract symptoms and suggestively linked to their development in asymptomatic men.