Sleep Problems Are Associated with Development and Progression of Lower Urinary Tract Symptoms: Results from REDUCE

The REDUCE study, involving 2,588 men over a 4-year period, found that sleep problems are significantly associated with the development and progression of lower urinary tract symptoms (LUTS). Men with worse sleep quality had a higher risk of developing LUTS, with a 14% development rate and a hazard ratio (HR) of 1.50 for those with the highest quartile of sleep scores. For men with existing LUTS, a 50% progression rate was observed, with an HR of 1.06 per 10-point increase in sleep score. The study suggests that poor sleep may precede LUTS and that addressing sleep issues could potentially improve LUTS outcomes, although further research is required to confirm these findings. Additionally, specific sleep problems like not feeling rested in the morning and trouble falling asleep were linked to LUTS progression, with HRs of 1.04 for each issue. The study also adjusted for various factors such as age, race, BMI, diabetes, and prostate health indicators.