Global Burden of Skin Disease as Reflected in Cochrane Database of Systematic Reviews

May 2014 in “ JAMA Dermatology ”

Chante Karimkhani, Lindsay N. Boyers, Laura Prescott, Vivian Welch, Finola M Delamere, Mona Nasser, Amrapali Zaveri, Roderick J. Hay, Theo Vos, Christopher J L Murray, David J. Margolis, John Hilton, Harriet MacLehose, Hywel C Williams, Robert P. Dellavalle

skin disease dermatitis disability-adjusted life years DALYs Global Burden of Disease GBD skin conditions eczema

TLDR The representation of skin conditions in medical reviews partly matches their real-world impact.

The study from September 1, 2014, evaluated the alignment between the Cochrane Database of Systematic Reviews (CDSR) and the global burden of skin diseases as indicated by disability-adjusted life years (DALYs) from the Global Burden of Disease (GBD) 2010 project. It was found that while all 15 skin conditions from the GBD 2010 were represented in the CDSR, there was a mismatch in the number of reviews/protocols to the DALYs for certain conditions. Dermatitis was both highly represented in CDSR and had a high DALY rank. Five skin diseases had a well-matched number of reviews to their DALYs, but three conditions were overrepresented and seven were underrepresented in the CDSR when compared to their DALYs. The study concluded that the representation of skin conditions in the CDSR is only partly correlated with their global burden, suggesting that future research and review topics could be better prioritized to align with the actual disease burden.

View this study on jamanetwork.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 2 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 1 month ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community Will stopping ketoconazole make a difference?

in Ketoconazole 11 upvotes 7 months ago

The user has been using finasteride and ketoconazole for hair loss and is considering changing shampoos due to dryness caused by ketoconazole. Responses suggest that stopping ketoconazole won't affect hair loss unless the user has seborrheic dermatitis, and recommend using conditioner or using ketoconazole shampoo less frequently.

community A hill on which I will die: The DHT itch absolutely exists

in Research/Science 209 upvotes 6 months ago

The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

Related Research

1 / 1 results

research Global Burden of Skin Disease as Reflected in Cochrane Database of Systematic Reviews

70 citations, May 2014 in “JAMA Dermatology”

The representation of skin conditions in medical reviews partly matches their real-world impact.