Does Variation in Either Age at Start of Therapy or Duration of Therapy Make Chemoprevention with Finasteride Cost-Effective?

    April 2011 in “ The Journal of Urology
    Suzanne Stewart, Charles D. Scales, Judd W. Moul, Shelby D. Reed
    TLDR Starting finasteride at age 65 and continuing until age 80 is the most cost-effective strategy for prostate cancer prevention.
    The study evaluated the cost-effectiveness of finasteride as a chemoprevention therapy for prostate cancer by varying the age at which therapy starts and its duration. Using a Markov model, the study found that starting finasteride at age 65 and continuing until age 80 was the most cost-effective strategy, with an incremental cost-effective ratio (ICER) of $65,600 per quality-adjusted life year (QALY). The analysis showed that starting therapy at age 50 had a higher ICER of $86,600 per QALY, and the cost-effectiveness decreased when therapy was initiated at older ages, peaking again at age 80. The findings suggested that the optimal age to begin finasteride for cost-effectiveness was 65, assuming equal effectiveness across ages and treatment durations.
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      by Taylor in General  71 upvotes 3 months ago
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