20 citations
,
November 2019 in “Biomolecules” This study found that finasteride impaired stress reactivity and reduced exploratory and impulsive behaviors in rats, potentially by altering the hypothalamus-pituitary-adrenal axis function.
2 citations
,
January 2016 in “Andrology” This case report study presents two instances of post-finasteride syndrome, highlighting the persistence of sexual adverse effects despite discontinuation of the drug, and underscores the need for increased awareness and understanding of this condition.
January 2025 in “SSRN Electronic Journal”
1 citations
,
December 2024 in “Qeios” This study found that a five-dimensional model of personality perception from men's facial photographs better captures the complexity of face perception than the traditional two-dimensional Valence-Dominance model, highlighting overlaps with personality structures known from differential psychology.
1 citations
,
June 2017 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride use may cause sexual dysfunction; more research needed.
July 2024 in “DergiPark (Istanbul University)” This review highlighted that childhood obesity is linked to early puberty and may impact brain function; however, there is a limited number of neuroimaging studies exploring the relationship between obesity, premature pubarche, and brain functionality, which warrants further research.
April 2018 in “Routledge eBooks” This article discusses the assumptions linking sex, gender identity, gender role, and sexual orientation, highlighting that these inferences are often incorrect, but it reports no new empirical results.
11 citations
,
April 2023 in “Annals of General Psychiatry” This study found that males treated with serotonergic antidepressants had an increased risk of erectile dysfunction, with an adjusted odds ratio of 3.2, and the risk for post-SSRI sexual dysfunction was 0.46%, emphasizing the importance of informed consent due to these potential irreversible side effects.
41 citations
,
November 2003 in “Annals of the New York Academy of Sciences” This article discusses the complexities of androgen and antiandrogen therapies in women, detailing diagnostic measures, the effects on libido, and the potential benefits of new progestins with antiandrogenic properties, but presents no new empirical findings.
May 2018 in “KU ScholarWorks (The University of Kansas)” This study found that in animal models of Tourette syndrome, stress-induced tic-like behaviors and sensorimotor gating deficits were reduced by finasteride, suggesting a role for neurosteroids like allopregnanolone.
9 citations
,
January 2009 in “PubMed” This study found that finasteride treatment in men with benign prostate hyperplasia significantly altered steroid hormone profiles and may contribute to depressive symptoms by affecting neuroactive steroid levels.
July 2001 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS” This article reviews the potential causes of insufficient androgen action during fetal development, such as enzyme and receptor gene mutations or environmental disruptors, but reports no new results.
47 citations
,
November 2002 in “Journal of Neurochemistry” This study found that progesterone pretreatment in rats potentiated the effect of ethanol on mesocortical dopamine levels, suggesting an influence of neuroactive steroids on ethanol's action.
2 citations
,
December 2023 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study, involving an international panel of 16 psychodermatology experts, proposed a new classification system for psychodermatology disorders that aims to unify previous classifications and improve their management by systematizing disorders into two main categories: primary mental health disorders and primary skin disorders.
February 2005 in “The Journal of Urology” This article evaluates sexual function using the International Index of Erectile Function in people taking finasteride for androgenetic alopecia but does not present new findings.
1 citations
,
November 2007 in “Neuro-chirurgie/Neurochirurgie” This study found that cyproterone acetate treatment in late-pubertal trans-girls was safe, well-tolerated, and induced mild feminizing changes, with more pronounced effects when combined with estrogens.
11 citations
,
January 2018 in “International Journal of Trichology” This commentary reviews the post-Finasteride syndrome and argues that while the condition's validity is debated, comprehensive guidelines are needed to address related risks and treatment options; it reports no new clinical results.
29 citations
,
May 2013 in “Andrologia” This review discusses the effects of cross-sex hormone treatments on metabolic functions in transgender individuals and reports no new clinical results; it highlights potential insights into the role of sex steroids in diseases like cardiovascular disease and diabetes.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study examines how conditions like PSSD, Long COVID, and ME/CFS form a "Post-Exposure Syndromes" family, initiated by transient exposures but persisting due to complex state-space dynamics, and suggests improving pharmacovigilance to better address and understand these persistent syndromes.
20 citations
,
March 1975 in “Clinics in Endocrinology and Metabolism”
July 2021 in “Advances in laboratory medicine” This article reviews differential diagnosis approaches for 46,XY DSD, proposing a diagnostic algorithm focused on biochemical and genetic data, without presenting new clinical results.
46 citations
,
January 2008 in “Climacteric” Randomized trials reported that testosterone therapy improved sexual function in postmenopausal women with hypoactive sexual desire disorder, particularly those who had undergone oophorectomy, with reversible and well-tolerated side effects.
April 2016 in “ValpoScholar (Valparaiso University)” This paper reviews the potential link between finasteride's adverse effects and factors like hand preference and sexual orientation, emphasizing the need for personalized therapeutic approaches in treating male androgenic alopecia.
June 2024 in “Drug and therapeutics bulletin” Finasteride can cause depression, suicidal thoughts, and lasting psychiatric and sexual issues.
October 2025 in “Environment International” This study reports that prenatal and prepubertal exposure to organochlorine compounds and perfluoroalkyl substances may affect pubertal development at age 12, with observed changes in development patterns in both girls and boys, highlighting the need for further research.
This study found that men experiencing persistent sexual side effects from finasteride also commonly report depressive symptoms and suicidal thoughts.
7 citations
,
October 2009 in “Journal of the American Geriatrics Society” This study found that finasteride may reduce inappropriate sexual behaviors in geriatric patients with vascular dementia and benign prostate hyperplasia without serious side effects, though some patients required additional medications.
2 citations
,
January 1988 in “Deep Blue (University of Michigan)” This study found that early adolescent girls who perceive themselves as undergoing pubertal changes report more intense and variable moods, with hormone activity and perceived pubertal status independently predicting mood fluctuations.
April 2022 in “The Journal of Sexual Medicine” This study found significant signals of sexual dysfunction associated with finasteride use, particularly in younger patients treated for alopecia, though confounding factors may partly contribute to reported cases.
116 citations
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December 2013 in “The Journal of Pediatrics” This study reported that treatment with gonadotropin-releasing hormone analogs and cross-sex hormones appears appropriate for carefully selected youth with gender dysphoria, but long-term safety needs further investigation.