Men And Women, So Different, So Similar: Observations From Cross-Sex Hormone Treatment Of Transsexual Subjects

    May 2013 in “ Andrologia ”
    Louis Gooren, Erik J. Giltay
    TLDR Cross-sex hormone treatment in transsexual individuals helps understand how sex hormones affect diseases like heart disease and diabetes.
    The document reviewed the effects of cross-sex hormone treatment in transsexual individuals, providing insights into how sex hormones influence metabolic functions. Natal males treated with anti-androgens and estrogens, and natal females treated with testosterone, offered a unique perspective on which metabolic functions are reversible and determined by the current hormonal environment. The study highlighted that while some sex differences in brain functions are gene-driven, many metabolic differences between men and women are influenced by sex hormones. These findings underscored the importance of considering sex steroids in understanding and treating conditions like cardiovascular disease and diabetes mellitus.
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