Estimating the Risk of Irreversible Post-SSRI Sexual Dysfunction Due to Serotonergic Antidepressants

    April 2023 in “ Annals of General Psychiatry ”
    Joseph Ben-Sheetrit, Yehonathan Hermon, Shlomo Birkenfeld, Yehiel Gutman, Antonei B. Csòka, Paz Toren
    TLDR Serotonergic antidepressants can significantly increase the risk of erectile dysfunction and have a small risk of causing irreversible sexual dysfunction.
    This study conducted a 19-year retrospective cohort analysis with 12,302 males to assess the risk of erectile dysfunction (ED) and post-SSRI sexual dysfunction (PSSD) associated with serotonergic antidepressants (SAs). The results indicated that SAs significantly increase the risk of ED, with a crude odds ratio of 3.6 and an adjusted odds ratio of 3.2. The risk of PSSD was found to be 0.46%, with a prevalence of 4.3 per 100,000. These findings highlight a small but significant risk of irreversible ED linked to SAs, emphasizing the importance of informed consent and consideration of alternative treatments in managing patients' sexual health.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Finasteride is one of the best decisions I ever made

      in Finasteride/Dutasteride  306 upvotes 2 years ago
      This conversation is about the effectiveness of Finasteride and Minoxidil as treatments for hair loss, with SnooBooks5080 claiming positive results from using both medications. However, other participants in the conversation caution that there are potential side effects to be aware of when taking Finasteride and advise people to do their research before making a decision.

      community Kevin if you can see this now, please don’t go.

      in Chat  553 upvotes 1 year ago
      Kevin, a YouTuber known for his channel "haircafe," helped many with hair loss through treatments like finasteride. He recently took down his channel and checked into a psych ward due to mental health issues and backlash over old posts.

      community NW5 at 19. How many grafts do I need?

      in Transplants  138 upvotes 2 years ago
      A 19-year-old with rapid hair loss since 16 is considering a hair transplant but refuses to take finasteride or any 5α-Reductase inhibitors. They are currently using minoxidil, tretinoin, and microneedling with a Derminator 2, and only want hair until age 27.

      community I really wish I started Propecia sooner

      in Finasteride/Dutasteride 2 years ago
      A 27-year-old man's experience with taking Finasteride to treat hair loss and the positive side effects he has experienced, such as improved skin. The user also shared their journey of how they were scared away from taking Finasteride due to fear of possible side effects before eventually deciding to take it.

    Similar Research

    5 / 1000+ results