148 citations
,
December 2018 in “Journal of autoimmunity” This review discusses genetic and environmental factors contributing to autoimmunity in alopecia areata and reports no new clinical findings, emphasizing the need for further study on its aetiology and pathophysiology.
February 2024 in “Health Sciences” This review discusses the non-cosmetic uses of botulinum neurotoxin A, including its effectiveness for idiopathic hyperhidrosis and potential use for androgenic alopecia, and reports no new clinical results; the authors highlight the need for more clinical trials.
5 citations
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August 2015 in “British journal of dermatology/British journal of dermatology, Supplement” The top research priorities for congenital ichthyosis include long-term side effects of oral retinoids, best topical treatments, and treatments for itch and hair loss.
108 citations
,
July 2004 in “American Journal of Pathology” This study suggests that nerve growth factor plays a crucial role in the stress-induced termination of hair growth in mice, and its antagonism might offer a therapeutic approach to mitigate stress-related hair loss.
48 citations
,
January 2002 in “Dermatology” In this study, hair pain (trichodynia) was reported by a significant portion of patients with hair loss, but it did not correlate with the cause or activity of the condition.
26 citations
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September 2018 in “Colloids and Surfaces B: Biointerfaces” This study reported that a novel liposomal formulation, SP-bFGF-SF-LIP, enhanced bFGF stability and skin permeability, significantly improving hair follicle recovery and wound healing in a mouse model.
16 citations
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December 2012 in “The Clinical Journal of Pain” This study found that trichodynia is associated with both peripheral and central sensitization, potentially linked to hair cycle abnormalities and chronic pain through proinflammatory agents.
4 citations
,
January 2021 in “Skin appendage disorders” This review discusses the complex causes of trichodynia and reports no clinical results; the authors call for more research into neural and immune interactions in scalp conditions.
June 2026 in “Dermatology and Therapy” In this retrospective analysis, patients with trichodynia who were unresponsive to standard treatments showed significant symptom improvement after receiving intradermal botulinum toxin type A, with nearly all patients benefiting, particularly those with scarring alopecia.
55 citations
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August 2008 in “Reviews in endocrine and metabolic disorders” This review discusses clinical, hormonal, and genetic aspects of nonclassic adrenal hyperplasia and reports no new findings; the condition is highlighted as a potential cause of premature adrenarche and other symptoms in young people.
24 citations
,
January 2010 in “Annales d'endocrinologie” This review discusses treatment options for hirsutism in women of childbearing age, focusing on the use of contraceptives, CPA, spironolactone, and third-line therapies, and reports no clinical results.
22 citations
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November 2014 in “Psychiatric Clinics of North America” This article reviews stress-related skin reactions, psychodermatology, and neuropsychiatric skin manifestations, and reports no new clinical results.
19 citations
,
March 2018 in “Expert Opinion on Drug Safety” In this narrative review, the researchers reported that the overall safety profile of drugs used for treating spondyloarthritis is generally good, with serious adverse events being rare, but emphasized the need for rheumatologists to tailor treatments and closely monitor patients for potential adverse events.
1 citations
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May 2008 in “Toxicon” This study found that BOTOX doses of 75–100 U effectively reduce postvoiding residual urine and detrusor pressure in patients with detrusor sphincter dyssynergia.
January 2010 in “Yearbook of Endocrinology” Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.
33 citations
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April 2009 in “Clinical and Experimental Dermatology” This study observed that psychological factors and serum levels of zinc, folate, and vitamin B12 may contribute to the development of trichodynia.
30 citations
,
September 2003 in “Experimental Dermatology” In this study on a murine model, researchers observed that a 5% minoxidil solution reduced stress-induced changes in hair growth, suggesting its potential for managing stress-related hair loss in humans.
2 citations
,
January 1998 in “Dermatology” Stopping forehead irritation and using hydrocortisone helped a man's skin, Martinique has lower melanoma rates, a man had an allergy to a specific antifungal, another had unexplained cysts, certain drugs can cause skin reactions without always being interrelated, a link between Fanconi anemia and a skin condition was suggested, high levels of a certain protein may play a role in a type of psoriasis, and there's a need to study the connection between scalp pain and hair loss.
January 2026 in “Dermatology and Therapy” This study suggests a possible bidirectional relationship between sleep quality and hair loss, indicating that addressing sleep disturbances might improve hair loss management and patient well-being.
September 2004 in “Experimental dermatology” This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.
This review examines complex regional pain syndrome (CRPS I) mechanisms, including immune dysregulation and psychological factors, but reports no new clinical results; the authors highlight potential diagnostic refinements.
301 citations
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May 1998 in “Genes & Development” Ets2 gene is crucial for placental development in mice.
291 citations
,
April 2010 in “Gastroenterology” This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.
204 citations
,
October 1999 in “EMBO journal” This study found that overexpression of activin in transgenic mice led to enhanced granulation tissue formation after skin injury due to changes in keratinocyte proliferation and differentiation.
199 citations
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April 2010 in “Nature” A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.
174 citations
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November 2016 in “Cell stem cell” This study found that squamous cell carcinomas from hair follicle stem cells are more prone to epithelial to mesenchymal transition and metastasis than those from interfollicular epidermis, due to distinct chromatin landscapes.
156 citations
,
January 1989 in “Genes & Development” This study found that keratin K14 expression occurs early in epidermal cell differentiation, while a hair-specific keratin is expressed later in hair matrix cells, suggesting developmental divergence between the two cell types.
133 citations
,
February 2017 in “PLoS Genetics” In this study, researchers used genetic data from over 52,000 men to identify over 250 genetic loci associated with severe hair loss and developed a predictive algorithm for determining hair loss risk.
103 citations
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November 2014 in “Journal of Cell Biology” This study found that overexpression of miR-214 in keratinocytes inhibits hair follicle development and cycling by targeting β-catenin in the Wnt signaling pathway.
100 citations
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November 2021 in “Cell Research” This study found that SARS-CoV-2 hijacks the host factor IGF2BP1 to stabilize its RNA and enhance translation, and identified Cepharanthine and Trifluoperazine as potential treatments against the virus.