18 citations
,
January 2016 in “Skin appendage disorders” The paper suggests improving diagnosis and treatment of telogen effluvium but does not recommend a new classification system.
13 citations
,
January 2016 in “Annals of Dermatology” This study found that acute stress in rats inhibits hair growth, likely through increased cortisol levels and activation of the substance P-mast cell pathway.
8 citations
,
May 2017 in “Chinese Journal of Integrative Medicine” Among in vitro and in vivo models, this study found that Miscanthus sinensis var. purpurascens flower extract may promote hair growth, potentially by modulating growth factor expressions and facilitating earlier hair follicle transitions in treated mice.
7 citations
,
April 2013 in “Clinical and Experimental Dermatology” This study found that tianeptine may suppress the transition to catagen, promoting hair growth in a stress-induced alopecia areata mouse model.
7 citations
,
October 1992 in “PubMed” This study investigated peptidergic nerve fibers in sinus hair follicles of various mammals and found that CGRP fibers were more densely distributed than SP fibers across different regions of the follicles.
6 citations
,
December 2019 in “BMC Complementary and Alternative Medicine” This study found that the alcohol extract of Vernonia anthelmintica may counteract stress-induced hair follicle growth inhibition in mice, potentially offering a new approach for treating stress-related hair loss.
3 citations
,
July 2023 in “International journal of molecular sciences” This review discusses the association between emotional stress-related neuropeptides and the pathogenesis of alopecia areata, reporting no new experimental findings.
3 citations
,
January 2022 in “Neurotoxicity Research” This study found that botulinum toxin type A injections in stressed mice appeared to normalize hair follicle regeneration cycles and reduced stress-related hair loss indicators.
1 citations
,
July 2024 in “JAAD Case Reports” This study links scalp pruritus in lichen planopilaris and its variants to the inflammation-induced release of substance P and calcitonin gene-related peptide by sensory nerves around hair follicle inflammation sites.
1 citations
,
April 2022 in “Journal of The American Academy of Dermatology” This study found that decreased pressure sensitivity and 2-point discrimination at the scalp's vertex were significantly associated with androgenetic alopecia in men.
March 2025 in “Frontiers in Cell and Developmental Biology” This study reviewed how neuropeptides and cutaneous innervation play crucial roles in the process of wound healing, suggesting they significantly influence inflammation and tissue repair phases.
July 2024 in “Journal of Investigative Dermatology” Certain substances can help skin cells become anti-inflammatory, aiding in tissue repair.
January 2024 in “Journal of dermatology and skin science” In this study, researchers found that applying topical aprepitant, which blocks substance P receptors, significantly reduced facial dermatitis and hair loss in rats experiencing erlotinib-induced skin side effects, highlighting the neurogenic inflammation's role and the protective effect of ROS inhibition.
April 2017 in “InTech eBooks” This review discusses potential mechanisms and treatments for trichodynia, noting a lack of strong literature support and reporting no new clinical results; the authors highlight several hypotheses and available treatment options.
162 citations
,
August 2004 in “Journal of Investigative Dermatology” This study suggests that stress negatively affects hair growth by inducing inflammation and early hair cycle transitions in mice, which might inform strategies for managing stress-related hair loss in humans.
January 2022 in “Journal of Skin and Stem Cell” This review discusses trichodynia, its potential causes, and treatment options, but reports no new clinical findings.
8 citations
,
January 2024 in “Current Research in Food Science” This study found that using composite alginate hydrogels containing Aloe vera, CMC, and tragacanth can improve the encapsulation efficiency and protect pumpkin seed protein hydrolysates from degradation during simulated gastrointestinal digestion, potentially increasing their applicability as functional food components.
1 citations
,
January 2024 in “Journal of Food Processing and Preservation” This study found that adding microcapsulated pumpkin seed protein hydrolysate to aloe vera drinks improved antioxidant activity, taste, and shelf life, with chitosan-alginate microcapsules effectively inhibiting microbial growth during 30 days of refrigerated storage.
October 2022 in “Rheumatology (Bulgaria)” This case report details the challenging diagnostic journey of a 50-year-old woman with progressive supranuclear palsy, highlighting the disease's complex and variable clinical presentation.
7 citations
,
August 2017 in “Genetic testing and molecular biomarkers” This report suggests that patients with primary spontaneous pneumothorax should be evaluated for FLCN mutations, as they may indicate Birt-Hogg-Dube syndrome and associated cancer risks.
9 citations
,
March 2024 in “Journal of Biomaterials Applications” This study developed dissolving microneedles using specific polymers for transdermal delivery of rizatriptan benzoate, demonstrating improved drug skin penetration and significant alleviation of migraine symptoms in vivo compared to passive diffusion, suggesting potential advantages over conventional treatment methods for acute migraine.
15 citations
,
August 2020 in “American Journal of Pathology” This study found that insulin promotes corneal epithelial wound healing and nerve recovery in diabetic mice through Wnt signaling, suggesting its potential as a protective factor for diabetic corneal damage.
1 citations
,
January 2025 in “CPT Pharmacometrics & Systems Pharmacology” In this study, the researchers evaluated the exposure-response relationship of ritlecitinib on eyebrow and eyelash regrowth and concluded that the established models justify selecting a 50 mg dose for patients with severe alopecia areata, while highlighting differing efficacy among evaluation methods.
June 2026 in “Psychosomatic Medicine and General Practice” In this study, women with metabolic and mixed-type alopecia showed different coping strategies; metabolic alopecia patients predominantly used adaptive strategies like problem-solving, while those with mixed alopecia often exhibited maladaptive strategies such as avoidance, with these behaviors being linked to higher levels of psychological maladjustment.
March 2026 in “Psychosomatic Medicine and General Practice” This study found that women with mixed alopecia had significantly lower levels of hardiness and resilience compared to those with metabolic alopecia, and these lower adaptive resources were associated with increased psychological maladaptation.
May 2025 in “CPT Pharmacometrics & Systems Pharmacology” This study examined the safety profile of ritlecitinib, a drug for alopecia areata, and found that it does not cause significant QTc prolongation or severe lymphopenia, with no unique safety risks expected in adolescents.
109 citations
,
April 1997 in “Archives of Dermatological Research” The researchers reported that mast cell and nerve fiber interactions in mouse skin are highly selective for nerve fiber types and vary depending on the hair cycle phase.
67 citations
,
July 2016 in “Reviews in Endocrine and Metabolic Disorders” This review discusses the complex relationship between stress and various skin conditions, highlighting the role of the skin in the stress response and the brain-skin communication pathways, but reports no new research findings.
This review reports that thermal spring waters, enriched with a diverse hydrobiome, hold promising potential for use in dermocosmetics, as their bioactive compounds could enhance skin protection, repair, and appearance, benefiting conditions like atopic dermatitis and rosacea.
150 citations
,
October 2010 in “The American Journal of Pathology” This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.