This review supports iron deficiency anemia as a valid cause of chronic generalized pruritus and suggests potential mechanisms by which iron deficiency may lead to pruritus, but reports no new clinical results.
15 citations
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July 1968 in “JAMA” This letter describes a case where severe pruritus without visible skin disease was a presenting symptom of hyperthyroidism in a 43-year-old woman, highlighting a less common association with the condition.
12 citations
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February 2011 in “Equine veterinary education” This case report describes the clinical and diagnostic features of a mare with mammary lymphoma associated with anaemia and pruritus.
11 citations
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July 1968 in “JAMA” This letter describes a case where a 43-year-old woman experienced severe itching as the presenting symptom of hyperthyroidism, alongside hair loss and other hyperthyroid features.
6 citations
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September 1990 in “International Journal of Gynecology & Obstetrics” This case report describes a rare instance of pruritic urticarial papules and plaques of pregnancy in a 25-year-old caucasian primigravida during the third trimester, discussing management recommendations.
6 citations
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September 1988 in “Drug intelligence & clinical pharmacy” This report documents a case of dermatological toxicity associated with chronic minoxidil therapy, highlighting the emergence of a severe rash after three years of use, which recurred upon inadvertent rechallenge.
5 citations
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June 2015 in “British Journal of Dermatology” This article discusses the role of lysophosphatidic acid-induced histamine release in generalized pruritus among patients with primary sclerosing cholangitis and reports no new clinical results.
4 citations
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September 2021 in “Frontiers in allergy” This review discusses the shared biological mechanisms between allergy and autoimmunity, emphasizing pruritus as a central symptom in psychophysiological dermatoses, and reports no new clinical results.
3 citations
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March 2016 in “Experimental Dermatology” This study found that a hypomorphic mutation in the Hr gene contributes to the development of diet-induced pruritic atopic skin in mice, particularly when combined with dietary deficiencies of polyunsaturated fatty acids and starch.
2 citations
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December 2021 in “Journal of Veterinary Medical Science” This case report found that adding lokivetmab to prednisolone treatment improved and maintained remission of pruritus in a dog with cutaneous epitheliotropic lymphoma.
1 citations
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August 2022 in “International journal of women’s dermatology” This case report suggests that intradermal botulinum toxin type A may alleviate pruritus and reduce papules in Fox-Fordyce disease, improving quality of life without serious adverse effects for at least six months.
1 citations
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December 1997 in “Archives of dermatology” This report describes a case of trichostasis spinulosa, a condition with pruritic, black papules on the face caused by keratotic plugs with embedded vellus hairs.
April 2026 in “IntechOpen eBooks” This study reviews the complexities of burn-related skin complications, highlighting postburn pruritus, dyspigmentation, and the risk of malignant ulcers, while offering a framework for evidence-based management through various treatment approaches.
September 2025 in “PubMed” In this study, auricular electrostimulation effectively relieved dextran-induced pruritus in mice, comparable to loratadine treatment, and is attributed to down-regulating the H1R/TRPV1 signaling pathway and reducing inflammatory cells in the skin.
August 2025 in “Scientific Reports” In this study, researchers observed that intractable pruritus in anterior chest keloid lesions is linked to increased intraepidermal nerve fibre density and elevated expression of substance P, without differences in Langerhans cells across different keloid regions.
August 2024 in “Journal of Clinical Medicine” This study aimed to assess pruritus in lichen planopilaris and frontal fibrosing alopecia, analyzing its correlation with dermoscopic features, but it reports no specific clinical results.
April 2024 in “Indian dermatology online journal” This case report describes a 53-year-old woman with a rare presentation of trichostasis spinulosa on her breast and abdomen, featuring itchy, comedo-like lesions. Dermoscopy revealed diagnostic features that may eliminate the need for a biopsy, highlighting the potential for non-invasive diagnosis in such cases.
September 2023 in “Journal of the American Academy of Dermatology” This study found that in participants with notalgia paresthetica, 8 weeks of treatment with difelikefalin significantly improved itch intensity and increased the rate of strict complete response compared to placebo, starting as early as week 3.
This study used data mining of the FDA Adverse Event Reporting System to analyze drug-induced pruritus, revealing differences in gender, age, and weight among cases, and identified ophthalmic drugs and systemic antibacterials as common triggers, contributing to potential prevention and treatment strategies for pruritus.
June 2023 in “Clinical Cosmetic and Investigational Dermatology” This report describes a 60-year-old female with pretibial pruritic papular dermatitis who showed significant improvement of skin lesions after one month of treatment with oral pentoxifylline. The authors highlight the unique clinical and histological features of PPPD and propose pentoxifylline as a potential therapy.
December 2022 in “Journal of Paediatrics and Child Health” This article presents the case of a 14-year-old girl with persistent itchy papules in her armpits and pubic area, awaiting diagnosis details.
November 2021 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This article describes a case of pruritic folliculitis of pregnancy, a rare, benign skin condition that occurs in the later stages of pregnancy and resolves after delivery without affecting maternal or fetal health.
February 2019 in “Veterinarski glasnik” Guinea pigs' skin issues in the lumbar area may be caused by dermatological problems and need proper care.
September 2013 in “The veterinary nurse” This article discusses the management of pruritic skin diseases in cats, focusing on diagnosis and the importance of client communication, but reports no new clinical results.
February 2010 in “Emergency Medicine News” This case report describes a 36-year-old African American woman with discoid lupus resulting in skin lesions, highlighting the need for a multidisciplinary approach in managing cutaneous and systemic lupus symptoms.
56 citations
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November 1993 in “Journal of The American Academy of Dermatology” Capsaicin cream quickly relieved itching in two patients with brachioradial pruritus.
37 citations
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January 2019 in “BioMed Research International” This review highlights that scalp pruritus is a complex condition with various underlying causes, making it a challenge to diagnose and manage effectively. It emphasizes the need for comprehensive patient evaluation, history-taking, and personalized treatment strategies to address quality of life impacts.
13 citations
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July 2004 in “Pediatric dermatology” This case study describes a 9-year-old boy with monilethrix and associated abnormalities, suggesting a new, severe autosomal recessive variant termed "monilethrix syndrome.
1 citations
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July 2024 in “JAAD Case Reports” This study links scalp pruritus in lichen planopilaris and its variants to the inflammation-induced release of substance P and calcitonin gene-related peptide by sensory nerves around hair follicle inflammation sites.
In this case series, elderly patients with chronic pruritus reported substantial improvement after using a topical serum containing magnetized saline water, although more research is needed to confirm these results.