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Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.

Testosterone can build muscle and bone without enlarging the prostate when a specific enzyme is blocked.

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.

The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Finasteride may affect PNMT, causing side effects.

Finasteride treatment changes Cx43 in rat testes, possibly causing fertility issues.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Too much androgen can cause hair loss; finasteride may help.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Finasteride reduces new brain cells in male mice, possibly causing depression.

Certain Chinese herbs, especially Cacumen platycladi, can promote hair regrowth and reduce hair loss-related hormone levels in mice.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.

Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.

Hesperidin protects rat testicles from finasteride damage and improves sperm health.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.