11 citations
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January 2015 in “Skin pharmacology and physiology” In this study, oral collagen peptides increased certain gene expressions related to epidermis development and the hair cycle in hairless mice skin, suggesting potential links to hair health.
January 2017 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that oral collagen peptides increased the expression of genes related to epidermal and hair cycle development in hairless mouse skin.
This study found that oral collagen peptides increased expression of genes associated with epidermis development and the hair cycle in hairless mice, providing insights into their potential skin benefits.
March 2016 in “Institutional Repositories DataBase (IRDB)” This study discusses the effects of collagen hydrolysates and the dipeptide Pro-Hyp on gene expression related to hair and epidermis development in mouse skin and reports no new clinical results.
274 citations
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June 2011 in “Science” In Arabidopsis thaliana, this study found that proper O-glycosylation of extensins is crucial for root hair elongation and self-assembly of the cell wall.
63 citations
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May 2015 in “PloS one” This study found that GALT5 and GALT2 are redundant enzymes essential for O-glycosylation of AGPs, with mutations leading to significant growth and development defects in plants.
35 citations
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October 2017 in “Trends in Molecular Medicine” This research suggests that targeting the HIF-1α pathway via PHD inhibitors may enable regeneration similar to amphibians in mammals, potentially fast-tracking regenerative therapies from mice to humans.
69 citations
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December 2015 in “BMC plant biology” This study provides evidence that five Hyp-O-GALT genes are crucial for AGP galactosylation and that AGP glycans are vital for various aspects of plant growth and development.
19 citations
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January 1987 in “Dermatology” This review discusses the effects of minoxidil on human skin fibroblasts, reporting its potential to inhibit lysyl hydroxylase activity and DNA synthesis, suggesting it may have antifibrotic applications for collagen-related skin conditions.
38 citations
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June 2005 in “Matrix Biology” Minoxidil affects collagen-related genes, potentially helping treat fibrosis.
33 citations
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November 1994 in “Archives of Biochemistry and Biophysics”
December 2025 in “Frontiers in Nutrition” This review suggests that although hydrolyzed collagen peptides with certain supplements may improve skin elasticity and joint function, evidence for collagen's anti-aging and regenerative benefits remains inconsistent.
48 citations
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January 2018 in “Scientific Reports” This pilot study found that hair metabolome analysis may help differentiate pregnancy complications from healthy pregnancies by revealing significant metabolite differences between trimesters.
1 citations
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May 2017 in “Asian journal of medical sciences” This study found that dietary supplementation with collagen, chondroitin sulfate, low-molecular weight hyaluronic acid, Pycnogenol®, and coenzyme Q10 significantly improved skin hydration, elasticity, nail hardness, and hair condition in patients with age-related dermatological changes after 12 weeks.
March 2026 in “Food, Nutrition and Health.” This review highlights research reporting that oral collagen peptide supplements are effective in enhancing skin elasticity, hydration, and reducing wrinkles, although results vary across studies. Oral supplementation was generally well-tolerated, and further investigation is needed to optimize formulations and explore topical application challenges.
77 citations
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July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” This review discusses the impact of menopause-related oestrogen deficiency on skin ageing and suggests that oestrogen use may improve collagen and skin elasticity, but it reports no clinical trial results.
48 citations
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May 2015 in “NPJ microgravity” In this study, mice exposed to prolonged space conditions demonstrated skin atrophy, altered hair follicle cycles, and significant changes in the gene expression associated with skin muscle health.
33 citations
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February 2016 in “Journal of Experimental Botany” This study found that the receptor kinase RHS10 negatively regulates root hair growth in Arabidopsis thaliana by modulating growth duration and is associated with cell wall signal mediation, involving RNA catabolism and ROS accumulation.
26 citations
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February 2009 in “Drug Development Research” This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.
5 citations
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October 2025 in “International Journal of Nanomedicine” This review discusses the role of traditional Chinese medicine and bioactive materials in chronic wound healing and reports no new clinical results.
March 2014 in “CRC Press eBooks” Some nutrients and antioxidants may improve skin and hair health, but more research is needed to confirm these benefits.
45 citations
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February 2018 in “Journal of basic and clinical physiology and pharmacology/Journal of basic & clinical physiology & pharmacology” This review summarizes the ethno-medicinal uses, phytochemical constituents, and biological activities of Acorus calamus, highlighting its potential therapeutic benefits and the importance of further scientific work on this plant.
37 citations
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August 2014 in “Journal of experimental botany” This study identified the AtPRPL1 gene in Arabidopsis thaliana as being involved in cell elongation processes, despite unclear changes in cell wall composition from its altered expression.
2 citations
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January 2020 Certain dietary supplements can improve hair health.
1 citations
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March 2022 in “IntechOpen eBooks” This chapter discusses various aspects of collagen, proposing "extended collagen carential disease" as a new concept tied to nutritional deficiencies, notably Vitamin C's role in maintaining collagen health.
19 citations
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May 2022 in “International journal of molecular sciences” This study suggests that PRX01, PRX44, and PRX73 regulate extensin-mediated cell wall properties during root hair cell growth, influencing growth patterns, peroxidase activity, and cell wall thickness.
This review reports that oral collagen peptide supplements may improve skin elasticity, hydration, and wrinkle appearance while also supporting hair and nail health and wound healing, but emphasizes the need for longer, high-quality studies due to current research limitations and variability in findings.
2 citations
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August 2023 in “Marine drugs” In this study, fish-derived collagen hydrolysate from tilapia scales improved hair growth and skin health in both cellular and mouse models, reducing oxidative stress and inflammation while enhancing hair quality and promoting beneficial gene expression.
1 citations
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June 2018 in “Ukrainian Journal of Dermatology Venerology Cosmetology” Oral collagen improves skin, nails, hair, and reduces cellulite.
May 2025 in “International Journal of Trichology” In this study, Pilopeptan® Intensive, a nutritional supplement containing hydrolyzed collagen, Group B vitamins, and zinc, was found to significantly improve hair parameters in telogen effluvium patients, with sustained benefits observed posttreatment, although mild side effects were reported by some participants.