The Effects and Mechanisms of Collagen Peptides for Alleviating Skin Aging

March 2026 in “ Food, Nutrition and Health. ”

Kangkai Chen, Dongwei Ma, Xin Yang, Wei Luo, Nan Shang, Zhuo Wang, Wang Liao

collagen peptides skin elasticity skin hydration wrinkles oral collagen peptide supplementation topical applications transdermal delivery

Studysummary This review highlights research reporting that oral collagen peptide supplements are effective in enhancing skin elasticity, hydration, and reducing wrinkles, although results vary across studies. Oral supplementation was generally well-tolerated, and further investigation is needed to optimize formulations and explore topical application challenges.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This review highlights the potential benefits of collagen peptides in delaying skin aging, particularly through enhancing skin elasticity, hydration, and reducing wrinkles. Numerous clinical trials have supported these effects, although results vary due to differences in study design and participant characteristics. Oral collagen peptide supplementation is generally well-tolerated, with no serious adverse events reported. The review also explores the potential of topical applications, noting challenges in transdermal delivery. Despite promising findings, further research is needed to understand the mechanisms and optimize formulations for effective use in skin health.

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