18 citations
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September 1979 in “DMW - Deutsche Medizinische Wochenschrift” In this study, Diane was reported to effectively treat acne, seborrhoea, androgenic alopecia, and mild hirsutism in hirsute women, with its effectiveness influenced by the severity and duration of the condition.
7 citations
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March 2025 in “Cytotechnology”
1 citations
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May 2001 in “Pharmacology & Toxicology” This review discusses the preclinical findings on cyproterone acetate and suggests that while it has a low potential cancer risk for patients, its tumor effects in female rats may involve both genotoxic and mitogenic mechanisms.
1 citations
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June 1959 in “A M A Archives of Dermatology” In this study, treatment of alopecia areata, totalis, and universalis with methyl prednisolone and ACTH injections resulted in complete regrowth in 62% of male and 58% of female patients.
7 citations
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May 1977 in “Deutsche medizinische Wochenschrift/Deutsche Medizinische Wochenschrift” This article discusses the mechanisms and therapeutic use of antiandrogens, specifically cyproterone acetate and chlormadinone acetate, in gynecological treatments without reporting new clinical results.
2 citations
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March 2023 in “Experimental neurology” In this study, pregnenolone was found to dose-dependently reduce L-DOPA-induced dyskinesias in a rat model of Parkinson's disease, suggesting its potential as a therapeutic target for these dyskinesias.
December 2005 in “Endocrine-related cancer” This case report describes a 57-year-old woman's virilizing adrenal tumor effectively treated with the antiandrogen cyproterone acetate, which led to symptom reversal and tumor resolution.
10 citations
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December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This case report describes a patient with severe alopecia areata and multiple autoimmune diseases who showed excellent hair regrowth after treatment with prednisone and cyclosporine, though she later developed hyperpigmentation.
232 citations
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June 1975 in “Journal of Steroid Biochemistry” In this study, a treatment regimen combining cyproterone acetate and ethinyl estradiol significantly improved acne and seborrhoea in most women after three months, but had varied effects on hirsutism and alopecia.
49 citations
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April 1997 in “Human reproduction” This study found that both a high dose of CPA and GnRHa are effective for treating hirsutism in hyperandrogenic women, but GnRHa with add-back therapy may lead to a longer remission period.
May 2020 in “International Journal of Clinical Obstetrics and Gynaecology” This article reviews the medical history and symptoms related to hyperandrogenism in patients, but reports no new clinical findings.
15 citations
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May 1966 in “The Journal of Urology” This case report discusses an instance of cystitis caused by the chemotherapy drug Cytoxan, with no new findings reported.
97 citations
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January 2006 in “Dermatology” This study found that intramuscular triamcinolone acetonide or pulse therapy effectively treats alopecia areata with manageable side effects, but further strategies are needed to reduce relapse rates.
12 citations
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August 2017 in “Pharmaceutical medicine” This study found that physician knowledge of thromboembolism risk associated with cyproterone acetate/ethinylestradiol was generally high, although it varied for complex or less common topics.
11 citations
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August 2021 in “Stem Cell Research & Therapy” This study found that coadministration of pimecrolimus may interfere with the therapeutic efficacy of mesenchymal stem cell therapy in atopic dermatitis.
February 1999 in “Analytical Sciences” A new antiandrogen compound was made and its detailed three-dimensional shape was described.
May 1981 in “Inpharma (Balgowlah)” Medroxyprogesterone acetate improved sleep apnea symptoms in some obese patients.
November 2025 in “Cochrane Database of Systematic Reviews” This study observed some differences in clinical outcomes when comparing CPA with spironolactone, flutamide, and finasteride, but no differences with other therapies, possibly due to small study size and non-standardized assessments; adverse effects could not be fully compared across treatments.
October 2025 in “Frontiers in Endocrinology” This study confirmed that methimazole use is associated with agranulocytosis, pyrexia, exposure during pregnancy, and hyperthyroidism, while also identifying new safety signals like premature birth and septic shock that require further investigation.
June 2010 in “Journal of Chemical Crystallography” This study determined the crystal structure and conformation of synthesized 17x-Acetoxy-pregn-4,6-diene-3,20-dione, revealing specific molecular interactions and structural details in an orthorhombic crystal system.
2 citations
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January 2011 in “Andrologia” This study concluded that 16β-methyl-17α-benzoyloxypregnen-4-en-3,20-dione may be a promising treatment for androgen-dependent diseases and epilepsy due to its antioxidant effects and impact on GABAergic and serotonergic metabolism in rats.
January 2002 in “대한피부과학회지” This study found that oral cyclosporine combination therapy led to new hair growth in 71% of patients with severe and refractory alopecia areata, though mild and transient side effects were common.
64 citations
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March 1984 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” In this study, cyproterone acetate combined with estradiol dramatically improved hirsutism symptoms and significantly reduced plasma testosterone and androstenedione levels in patients over periods of up to three years.
This study found that men with early-onset androgenic alopecia may be partially resistant to the cardiometabolic benefits of bromocriptine compared to those with normal hair growth.
7 citations
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August 2000 in “Journal of Pediatric and Adolescent Gynecology” This review discusses perceptions and side effects of depot medroxyprogesterone acetate and emphasizes the importance of educating teens to enhance compliance; it reports no new clinical findings.
January 2014 in “Progress of Digestive Endoscopy” This case report describes a 60-year-old woman with Cronkhite-Canada syndrome whose symptoms and polyposis improved following prednisolone therapy, but emphasizes the need for periodic digestive tract screening due to associated cancer risks.
July 2008 in “International journal of psychophysiology” This retrospective study found that cyproterone acetate, both alone and with estrogens, was safe, well tolerated, and induced modest feminizing effects in late-pubertal transgender female adolescents.
36 citations
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April 1994 in “PubMed” This study introduces a mouse model of cyclophosphamide-induced alopecia, which effectively replicates human chemotherapy-induced hair loss and can be pharmacologically manipulated to study hair regrowth patterns.
August 2023 in “Portuguese journal of dermatology and venereology” Cyclosporine can reverse hair graying.
17 citations
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August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that a specific amino-pyridine compound showed potent androgen receptor antagonist activity, stimulating hair growth in mice and reducing sebum production in a hamster model.