This study explored the structure and function of lipocalin prostaglandin D synthase, revealing its dual role in substrate catalysis and as a lipophilic ligand carrier, potentially informing future drug delivery design.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a mutation in the CST6 gene linked to a rare syndrome with symptoms affecting hair and skin, revealing cystatin M/E's role in maintaining epidermal homeostasis and hair follicle development.
August 2019 in “Journal of Investigative Dermatology” This study suggests that epidermal turnover could be a regulated mechanism of iron excretion, with systemic iron levels influencing keratinocyte behavior and differentiation markers in the skin.
August 2019 in “Journal of Investigative Dermatology” This study found that the desmosomal protein desmoplakin is crucial for proper epidermal morphogenesis and radial intercalation in developing Xenopus embryos, affecting keratin organization and ectodermal structures.
January 2019 in “Advances in Environmental Biology” This article discusses the structure and function of sebaceous glands and their role in skin moisture but reports no new research findings.
This review found that antimalarial agents were more effective than steroids for Lichen planopilaris, while finasteride and dutasteride showed favorable impacts on frontal fibrosing alopecia, despite heterogeneous study quality.
July 2018 in “Elsevier eBooks” This review discusses the evolving understanding of frontal fibrosing alopecia as a generalized skin condition with diverse manifestations, and reports no new clinical results.
April 2018 in “Journal of Investigative Dermatology” This study suggests that with aging, mouse corneal renewal increasingly relies on Lrig1+ stem cells as CD44 expression and Wnt activity decline.
April 2018 in “Journal of Investigative Dermatology” This study found that dermal white adipose tissue surrounding human hair follicles enhances proliferation, pigmentation, and hair shaft elongation in an ex vivo setting.
February 2018 in “Trends in Immunology” This study demonstrated that antigens from the skin bacterium Staphylococcus epidermidis can stimulate CD8+ T cells, which in turn enhance wound healing.
January 2018 in “Stem cell biology and regenerative medicine” This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.
January 2017 in “Springer eBooks” The document concludes that scalp health is influenced by complex factors affecting sebaceous glands, including hormones, aging, and various substances.
This chapter reviews pharmacodynamic evaluations in endocrine disorders focusing on oral antidiabetics, insulin analogues, and hormone interactions, but reports no new results.
This review discusses the roles and characteristics of skin stem cells, their niches, and signaling pathways in skin maintenance, aging, and cancer, highlighting their potential in therapeutic applications but presenting no new clinical findings.
August 2016 in “Journal of Dermatology” This research successfully established a novel mouse model for anagen effluvium using BrdU treatment, which induced hair loss and pathological changes mimicking human symptoms.
Lichen planopilaris and frontal fibrosing alopecia are likely the same disease with different clinical appearances.
December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)” This study showed that regulation of adipose androgen generation via AKR1C3 may contribute to a cycle of hyperinsulinaemia and lipid accumulation in women with PCOS.
July 2015 in “Cambridge University Press eBooks” Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.
January 2015 in “Durham e-Theses (Durham University)” This study found that glucose starvation and hypoxia are physiological triggers of ER stress in in vitro differentiated adipocytes, rather than high concentrations of saturated fatty acids, cholesterol, or proinflammatory cytokines.
September 2014 in “Springer eBooks” This review discusses how sex hormone levels and local steroid synthesis influence gender differences in aging skin, reporting no new clinical results.
Chemicals and stem cells combined have advanced regenerative medicine with few safety concerns, focusing on improving techniques and treatment effectiveness.
March 2014 in “Journal of The American Academy of Dermatology” The document lists various dermatology topics, treatments, and diagnostic methods.
February 2014 in “Medicine - Programa De Formación Médica Continuada Acreditado” This paper reviews various types of scarring and non-scarring alopecia, including their etiology, diagnosis, and treatment, but it reports no new clinical results.
February 2013 in “Journal of the American Academy of Dermatology” This case report found that intense focused skin tightening ultrasound reduced excessive underarm sweating by nearly 80% in two patients and was associated with temporary side effects like tenderness and redness.
February 2012 in “InTech eBooks” This review discusses the impact of polycystic ovary syndrome on cardiovascular risk and reports no new clinical findings.
This study reviewed and reclassified 37 cases of primary scarring alopecia using histological methods to achieve more accurate diagnoses within subtypes like lupus erythematosus and lichen planopilaris.
January 2011 in “Springer eBooks” Eating a balanced diet with the right vitamins and minerals is important for healthy hair, but too many supplements can be harmful.
May 2010 in “Journal of the Dermatology Nurses' Association” This article discusses cicatricial alopecias, focusing on diagnosis and management strategies, but reports no new clinical findings.
January 2009 in “Elsevier eBooks” This chapter reviews botanical treatments for polycystic ovary syndrome, discussing potential benefits but presenting no new clinical results; it emphasizes the use of botanicals for managing symptoms like anovulation, insulin resistance, and inflammation.
July 2026 in “Organoid Research” In this review, researchers summarize key factors in constructing skin organoids, including cell source and assembly methods, and emphasize advances such as air-liquid interface culture for improving tissue development, aiming to guide standardized protocols and future clinical applications.