July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review discusses the process and benefits of Platelet-Rich Plasma therapy for hair restoration, emphasizing its safety and potential for encouraging hair growth, but reports no new clinical results.
9 citations
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March 2017 in “Journal of Visualized Experiments” This study introduced a novel in vitro murine assay using transgenic mice to identify immunomodulatory compounds, which identified 160 potential hits from 4,398 compounds screened.
8 citations
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June 2013 in “Journal of bone and joint surgery. American volume/The Journal of bone and joint surgery. American volume” This commentary highlights that while platelet-rich plasma (PRP) is widely used in orthopaedic and cosmetic treatments, its effectiveness is questionable and varies with different compositions and applications.
August 2024 in “British Journal of Dermatology” The trial is ongoing, but researchers are evaluating the efficacy and safety of REZPEG, a potential new therapy for severe alopecia areata, which selectively expands regulatory T cells.
March 2026 in “Frontiers in Pharmacology” The study concluded that the Exprecell™ device for preparing anticoagulant-free f-PRF increases volume yield and simplifies the process while maintaining biological activity comparable to conventional methods, suggesting potential clinical utility.
December 2019 in “Medicina estética/Medicina estética” This review discusses the use of platelet-rich plasma as an adjunctive treatment for patients undergoing hair transplant and reports no clinical results; the authors suggest it could be beneficial but emphasize the need for scientific evidence.
2 citations
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April 2022 in “Indian Journal of Dermatology, Venereology and Leprology” This pilot study suggests that platelet-rich plasma may be a promising treatment for chronic telogen effluvium with good safety, and cost-effective preparation methods may be reliable alternatives to more expensive ones.
13 citations
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January 2021 in “Regenerative Medicine” This review examines the potential applications of human platelet lysates in regenerative medicine but reports no new experimental findings.
October 2025 in “Journal of Advanced Trends in Medical Research” This review discusses the potential of platelet-rich plasma and exosome-based therapies for treating various types of alopecia, highlighting their promise but noting the need for more research on standardization and efficacy.
May 2014 in “Transfusion and Apheresis Science” The study found that the quality of cord blood units remains consistent before freezing and after thawing, indicating that attached tube segments reliably represent the graft's properties.
April 2017 in “Plastic surgical nursing” Platelet-rich plasma (PRP) is an effective treatment for hair loss that involves scalp injections and requires ongoing maintenance.
348 citations
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July 2017 in “Skin appendage disorders” This review discusses the use of platelet-rich plasma in dermatology for various applications such as tissue regeneration and wound healing, but it reports no new clinical results and calls for clearer guidance on suitable treatments.
May 2005 in “Molecular Carcinogenesis” This study found that mrp/plf-mRNA expression in murine skin increases in response to different tumor promoters, suggesting its potential as a short-term biomarker for chemical carcinogenesis.
2 citations
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April 2021 in “JAAD International” This article discusses the potential safety of platelet-rich plasma therapy for cicatricial alopecia but highlights that its effectiveness is still uncertain; no new empirical results are provided.
November 2025 in “The Journal of Immunology” This study observed that in human scalp hair follicles, BTNL2 expression is lower in stressed conditions, which correlates with increased cytotoxic activity by gamma/delta and CD8+ T cells, suggesting a possible role for BTNL2 in controlling immune responses relevant to alopecia areata.
1 citations
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May 2022 in “Journal of Drugs in Dermatology” This case report describes a patient with lichen planopilaris who experienced remarkable hair regrowth at a previously scarred area after treatment with low-dose naltrexone and platelet-rich plasma, following minimal response to other therapies.
January 2024 in “Wiadomości Lekarskie” This paper reviews the development and implementation of CAR-T cell therapy as a significant advancement in treating pediatric hematological malignancies, particularly for children with relapsed or chemotherapy-resistant acute lymphoblastic leukemia, offering renewed remission prospects where conventional methods are ineffective.
November 2025 in “Advanced Science” In this study, researchers found that a cold atmospheric plasma-activated hydrogel containing interleukin-2 significantly enhanced hair regeneration in a depilated mouse model, promoting larger hair follicles and faster hair growth phase transition, suggesting it as a potential treatment for hair loss.
2 citations
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June 2021 in “Cosmoderma” This article reviews the use of platelet-rich plasma (PRP) in various dermatological conditions and reports no new clinical results; the authors emphasize its efficacy and call for continued careful use.
99 citations
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April 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that human hair follicles serve as a crucial reservoir for Langerhans cells, which repopulate the epidermis depleted by ultraviolet B exposure.
1 citations
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May 2024 in “Skin Appendage Disorders” In this case study, researchers reported that a patient with plaque alopecia areata experienced complete and sustained hair regrowth after treatment with 5-Fluorouracil and Bleomycin via microinfusion of medicines, despite initial cutaneous atrophy caused by intralesional corticosteroid therapy.
September 2019 in “Journal of Investigative Dermatology” This study suggests that in alopecia areata, innate lymphoid cells type 1 may contribute to the disease’s pathogenesis by inducing hair follicle changes similarly to CD8+ T cells.
January 2021 in “American journal of dermatological research and reviews” This study concluded that myositis in the reported case was caused by T-cell large granular lymphocytic leukemia, not dermatomyositis.
46 citations
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October 2018 in “JCI insight” In this study, the researchers found that treatment with the JAK inhibitor tofacitinib in alopecia areata patients may reduce clonal CD8+ T cell expansions but does not eliminate them entirely, which could contribute to disease relapse.
January 2023 in “Indian dermatology online journal” In this case report, an 8-year-old boy's crusted scalp lesions and alopecia initially mimicking kerion were ultimately diagnosed as Pre-B acute lymphocytic leukemia after histopathological evaluation revealed leukemia cutis.
1 citations
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April 2024 in “Clinical Medicine” This case report suggests that Rituximab and high-dose immunosuppressive therapy may be effective for treating severe cutaneous lupus erythematosus like TEN-like ACLE, leading to remission and recovery.
August 2025 in “International Journal of Research in Dermatology” This study found that adding cyclophosphamide to glucocorticoid treatment for pemphigus patients led to earlier remission, with 89.5% achieving remission within 4 months compared to 73.9% with glucocorticoids alone, suggesting significant steroid-sparing effects and improved clinical outcomes.
2 citations
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September 2024 in “World Journal of Clinical Cases” This case report describes how autologous platelet-rich plasma treatment led to complete healing of a chronic wound in a 72-year-old male patient after other standard treatments failed.
February 2020 in “Int J Biologicals” This study found that super-activated platelet lysate increased hair follicle density in a mouse model of androgenetic alopecia, outperforming platelet-rich plasma and platelet lysate.
68 citations
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September 2003 in “British Journal of Dermatology” This study found that in thin cutaneous melanomas, tumor regression is associated with a higher risk of sentinel lymph node involvement.